NUI
No nā nīnau e pili ana i kā mākou huahana a i ʻole ka papa inoa kumukūʻai, e ʻoluʻolu e waiho i kāu leka uila iā mākou a e hoʻopili mākou i loko o 24 mau hola.
NINAU ANOKūlana halihali
Hiki i ka wela maʻamau
Manaʻo i ke ʻano hoʻouna
Ma ka lewa Ma ka aina Ma ke kai
Kūlana mālama:
E mālama i kahi pōʻeleʻele, Inert ea, lumi wela
Ola ola
Ma kahi o 2 makahiki
Ka nui o ke kauoha liʻiliʻi:
1kg (kūkākūkā)
palapala hōʻoia:COA, wahi hehee, Hoʻololi kikoʻī [α]D20
E hoʻouna mākou i nā ʻikepili āu e makemake ai.Hiki iā ʻoe ke ʻike i ka ʻikepili ma mua ma ke ʻano he kuhikuhi.
No nā huahana maʻamau, hoʻouna mākou i ka ʻikepili hou ma hope o ka puka ʻana mai.
NT-BOC-N-METHYL-D-PHENYLALANINEDICYCLOHEXYLAMMONI;
Boc-DN-Me-Phe.DHCA;
Boc-Nalpha-methyl-D-phenylalanine.DCHA;
dicyclohexylamine(R)-2-(tert-butoxycarbonyl(methyl)amino)-3-phenylpropanoate;
N-ALPHA-(BOC)-N-ALPHA-METHYL-D-PHENYLALANINEDICYCLOHEXYLAMINE;
N-tert-BOC-N-methyl-D-phenylalaninedicyclohexylammonium;
Boc-N-methyl-D-phenylalaninedicyclohexylammoniumsalt≥99%(HPLC)
Hoʻohana pinepine ʻia lākou no ka hoʻopili ʻana i ka pauka.Pili ia i nā koi o nā mea kūʻai aku.No laila, e haʻi mai iā mākou i kāu koi ma mua o ka hoʻopaʻa ʻana inā loaʻa iā ʻoe nā noi kūikawā.
1kg a 25kg He paʻakikī ka paʻi waho.A he mea paʻakikī ke ʻoki a hōʻino.Hiki iā ia ke pale pono i kāu mau huahana.
ʻO ka peptide Synthesis a me ka hoʻomaʻemaʻe:
Hiki ke hoʻohana ʻia ʻo Boc-DN-Me-Phe-DCHA ma ke ʻano he hale kūkulu hale i ka synthesis peptide solid-phase.ʻO kona ʻano pale e hiki ai ke hoʻohui pū ʻia o nā waikawa amino me ka ʻole o nā hopena ʻaoʻao makemake ʻole.Hoʻonui pinepine ka ʻano paʻakai (DCHA) i ka solubility a me ka paʻa, hoʻomaʻemaʻe i ka hoʻomaʻemaʻe a me ka hoʻokaʻawale ʻana o ka peptide intermediate i ka wā synthesis.
ʻO ka hoʻopaʻa inoa Stereoselective:
No ka loaʻa ʻana o Boc-DN-Me-Phe-DCHA i kahi waikawa D-amino, hiki ke hoʻohana ʻia i ka synthesis o nā peptides me kahi chirality kikoʻī (D-configuration).He mea koʻikoʻi kēia ala stereoselective i kekahi mau ʻano olaola kahi e hiki ai i ka stereochemistry o nā waikawa amino ke hoʻopili i ka hana a me ka hana o nā peptides.
Nā haʻawina olaola:
Hiki ke hoʻohana ʻia nā peptide i loaʻa iā Boc-DN-Me-Phe-DCHA ma ke ʻano he ʻimi noiʻi i loko o nā haʻawina olaola e noiʻi ai i ka pilina protein-protein, ka hoʻopaʻa ʻana i ka mea hoʻopaʻa, a i ʻole ka pāpā ʻana i ka enzyme.Hiki i ka D-configuration o ka amino acid ke hāʻawi i nā ʻike koʻikoʻi i nā koi hoʻolālā no ka ʻike olaola a me ka hana.
ʻIke lāʻau lapaʻau:
ʻOiai ʻoi aku ka liʻiliʻi ma mua o ka L-amino acid-based peptides, D-amino acid-containing peptides hiki ke loaʻa nā ʻano lāʻau lapaʻau kūikawā.Hiki ke lilo ʻo Boc-DN-Me-Phe-DCHA i mea o ka moho lāʻau peptide me nā hana therapeutic novel.
Noi ʻepekema Material:
Hiki ke hoʻohana ʻia nā peptide a me nā polymers i loaʻa nā ʻāpana Boc-DN-Me-Phe-DCHA i nā noiʻi ʻepekema waiwai e like me nā hydrogels biocompatible, tissue engineering scaffolds, a i ʻole biosensors.Hiki i ka chirality a me nā waiwai kemika o kēia mau ʻāpana ke hāʻawi i nā waiwai kino a i ʻole nā mea ola kino i ka mea.
Boc-N-Me-L-Phe-OH | ZN-Me-L-Phe-OH | Fmoc-N-Me-L-Phe-OH | BOC-N-Me-D-Phe-OH |
FMOC-N-Me-D-Phe-OH | Boc-N-Me-L-Phe-OH.DCHA | N-Me-D-Phe | Fmoc-N-Me-D-Leu-OH |
Boc-N-Me-DL-Phe-OH | HN-Me-L-Phe-OH | HN-Me-L-Phe.Hcl |
1. No ka MOQ: Hiki iā mākou ke hoʻololi e like me kāu koi.
2. E pili ana i ka hāpana: Pono ka hāpana i ka uku hōʻailona, hiki ke lawe i ka ukana e hōʻiliʻili aiʻole hiki iāʻoe ke uku iā mākou ma mua.
3. Mold workshop, hiki ke hoʻopilikino ʻia e like me ka helu o nā hiʻohiʻona.
4. Hāʻawi mākou i ka lawelawe maikaʻi loa.Ke hana nei kekahi hui kūʻai akamai iā ʻoe.
5. E pili ana i ka hoʻololi: E ʻoluʻolu e leka uila a kamaʻilio mai iaʻu ma kou ʻoluʻolu.