NUI
No nā nīnau e pili ana i kā mākou huahana a i ʻole ka papa inoa kumukūʻai, e ʻoluʻolu e waiho i kāu leka uila iā mākou a e hoʻopili mākou i loko o 24 mau hola.
NINAU ANOKūlana halihali
Hiki i ka wela maʻamau
Manaʻo i ke ʻano hoʻouna
Ma ka lewa Ma ka aina Ma ke kai
Kūlana mālama:
E mālama i kahi pōʻeleʻele, Inert ea, lumi wela
Ola ola
Ma kahi o 2 makahiki
Ka nui o ke kauoha liʻiliʻi:
1kg (kūkākūkā)
palapala hōʻoia:COA, wahi hehee, Hoʻololi kikoʻī [α]D20
E hoʻouna mākou i nā ʻikepili āu e makemake ai.Hiki iā ʻoe ke ʻike i ka ʻikepili ma mua ma ke ʻano he kuhikuhi.
No nā huahana maʻamau, hoʻouna mākou i ka ʻikepili hou ma hope o ka puka ʻana mai.
Boc-L-Tyr(Et)-oL;
ʻAikika Carbamic, N-[(1S)-2-(4-ethoxyphenyl)-1-(hydroxymethyl)ethyl]-, 1,1-dimethylethyl ester;
Hoʻohana pinepine ʻia lākou no ka hoʻopili ʻana i ka pauka.Pili ia i nā koi o nā mea kūʻai aku.No laila, e haʻi mai iā mākou i kāu koi ma mua o ka hoʻopaʻa ʻana inā loaʻa iā ʻoe nā noi kūikawā.
He paʻakikī ke ʻoki a me ka pōʻino.Hiki i ka pahu paʻakikī ke pale i nā huahana mai ka hāʻule ʻana.ʻAʻohe pono e hopohopo e pili ana i ka pōʻino o ka pūʻolo.E hoʻouna mākou i nā kiʻi e pili ana i nā huahana a me ka pūʻolo iā ʻoe ma mua o ka lawe ʻana.
Noiʻi Biochemical: Hana ʻo Boc-L-Tyr(Et)-OL ma ke ʻano he mea hana waiwai i ka noiʻi biochemical, ʻoi aku hoʻi i ka synthesis, hoʻololi, a me nā haʻawina pili o nā peptides a me nā protein.Hiki iā ia ke lilo i ʻāpana o nā kaulahao peptide synthetic, mimicking a i ʻole ke keʻakeʻa ʻana i nā kaʻina peptide kikoʻī i loko o vivo e noiʻi i nā pilina me nā mea loaʻa, nā enzymes, a i ʻole nā biomolecules ʻē aʻe.
ʻIke Lapaʻau: Ma ke kahua o ka loaʻa ʻana o ka lāʻau, hiki ke hoʻohana ʻia ʻo Boc-L-Tyr(Et)-OL ma ke ʻano he precursor a i ʻole waena i ka synthesis o nā molekala lāʻau.Ma ka hana ʻana me nā ʻāpana ʻē aʻe o kahi mole lāʻau lapaʻau, hiki ke alakaʻi i ka hoʻokumu ʻana i nā moho lāʻau lapaʻau me nā hana olaola kikoʻī.Hiki i kēia mau moho ke hele hou i ka hoʻokolohua in vitro a me in vivo e loiloi i ko lākou pono a me ka palekana.
ʻOihana Lapaʻau: Ma ka ʻoihana lāʻau lapaʻau, lawelawe ʻo Boc-L-Tyr(Et)-OL ma ke ʻano he kumu a i ʻole waena i ka hana ʻana i nā lāʻau peptide therapeutically active.Ma o ka pilina me nā waikawa amino ʻē aʻe a i ʻole nā ʻāpana lāʻau, hiki ke alakaʻi i ka synthesis o nā lāʻau peptide me nā hana kūlohelohe kūikawā, e like me nā antibiotics, hormones, enzyme inhibitors, a me nā mea hou aku.
Fmoc-β-Ala-D-Tyr(Et) | L-Tyr-OL.Hcl | Boc-L-Tyr(Et)-OH | Boc-D-Tyr(bzl)-OL |
L-Tyr-OH | D-Tyr-Ome.Hcl | Boc-L-Tyr-OL | Boc-L-Tyr(bzl)-Ol |
D-Tyr-OH | L-Tyr(bzl)-Ome.Hcl | Boc-D-Tyr(bzl)-OL | Boc-L-Tyr(me)-OL |
D-Tyr(Et)-OH | D-Tyr-Oet•HCl | Boc-L-Tyr(bzl)-Ol | Boc-Tyr(Et).OL |
L-Tyr(Et)-OH | L-Tyr-Ome.HCl | Boc-L-Tyr(me)-OL | Boc-L-Tyr-Ome |
D-Tyr(Et).HCl | HL-Tyr-Oet.Hcl | Boc-Tyr(Et).OL | Boc-D-Tyr-Ome |
L-Tyr(bzl)-obzl.Hcl | Boc-L-Tyr-Oet | Boc-L-Tyr(Et)-OH | Boc-Tyr-Otbu |
L-Tyr(tbu)-OH | Boc-D-Tyr-Oet | Boc-L-Tyr-OL | Boc-DL-Tyr-Otbu |
1. Hāʻawi mākou i ka hana maʻamau i nā huahana āu e pono ai.
2. Hiki ke hāʻawi ʻia ke kumukūʻai kiʻekiʻe & hoʻokūkū.
3.We hoʻohiki i kahi papa piha o ka lawelawe ukali no ʻoe.
4. Hiki ke hā'awi 'ia ka nīnau nīnau mea kū'ai a me nā palapala 'ike loea inā noi ma hope o ka hālāwai 'ana i kekahi huina.
5. Nui ma hope o ke kūʻai aku ʻana a i ʻole ka hōʻoia ʻana: E hoʻoponopono koke ʻia kāu nīnau i ka hiki.
6. E hoʻokuʻu aku i nā huahana hoʻokūkū a hoʻokuʻu aku iā lākou i waho i nā mea nui i kēlā me kēia makahiki.
7.Free hāpana hāʻawi ʻia e nānā i ka maikaʻi ma mua o kekahi uku.