NUI
No nā nīnau e pili ana i kā mākou huahana a i ʻole ka papa inoa kumukūʻai, e ʻoluʻolu e waiho i kāu leka uila iā mākou a e hoʻopili mākou i loko o 24 mau hola.
NINAU ANOKūlana halihali
Hiki i ka wela maʻamau
Manaʻo i ke ʻano hoʻouna
Ma ka lewa Ma ka aina Ma ke kai
Kūlana mālama:
E mālama i kahi pōʻeleʻele, Inert ea, lumi wela
ola mālama
Ma kahi o 2 makahiki
Ka nui o ke kauoha liʻiliʻi:
1kg (kūkākūkā)
palapala hōʻoia:COA, wahi hehee, Hoʻololi kikoʻī [α]D20
E hoʻouna mākou i nā ʻikepili āu e makemake ai.Hiki iā ʻoe ke ʻike i ka ʻikepili ma mua ma ke ʻano he kuhikuhi.
No nā huahana maʻamau, hoʻouna mākou i ka ʻikepili hou ma hope o ka puka ʻana mai.
Fmoc-Lys(Pal-Glu-OtBu)-OH;
N2-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N6-[N-(1-oxohexadecyl)-L-gamma-glutamyl]-L-lysine1'-(1,1-dimethylethyl)ester;
(S)-2-((((9H-Fluoren-9-Yl)Methoxy)Carbonyl)Amino)-6-((S)-5-(Tert-Butoxy)-5-Oxo-4-Palmitamidopentanamido)HexanoicAcid;
(9H-Fluoren-9-yl)MethOxy]CarbonylLys(Pal-Glu-OtBu)-OH;
N-alpha-(9-Fluorenylmethyloxycarbonyl)-N-epsilon-(N-alpha'-palmitoyl-L-glutamic-acidalpha'-t-butylester) -L-lysine;
Fmoc-L-Lys(Palm-L-Glu-OtBu)-OH;
(2S)-6-[(4S)-5-(tert-butoxy)-4-hexadecanamido-5-oxopentanmido]-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)hexanoicacid;
L-Lysine,N2-[(9H-fluoren-9-ylmethoxy)carbonyl]-N6-[N-(1-oxohexadecyl)-L-γ-glutamyl]-,1'-(1,1-dimethylethyl)ester
Hoʻohana pinepine ʻia lākou no ka hoʻopili ʻana i ka pauka.Pili ia i nā koi o nā mea kūʻai aku.No laila, e haʻi mai iā mākou i kāu koi ma mua o ka hoʻopaʻa ʻana inā loaʻa iā ʻoe nā noi kūikawā.
1kg a 25kg He paʻakikī ka paʻi waho.A he mea paʻakikī ke ʻoki a hōʻino.Hiki iā ia ke pale pono i kāu mau huahana.
ʻO Fmoc-Lys(Pal-Glu-OtBu)-OH he hui me kahi ʻano kemika kikoʻī e loaʻa ai ka noi nui ma nā kahua o ka bioscience a me ka noiʻi a me ka hoʻomohala lāʻau.ʻO ke kikoʻī, hiki ke hoʻohana ʻia ma ke ʻano he mea hoʻopili ADC degradable no ka synthesis o nā antibody-drug conjugates (ADCs).ʻO nā ADC nā lāʻau lapaʻau e hoʻohui i nā molekole lāʻau me nā antibodies ma o nā loulou kikoʻī, e hiki ai ke kuhikuhi pololei a mālama i nā maʻi.Eia hou, lawelawe ʻo Fmoc-Lys(Pal-Glu-OtBu)-OH ma ke ʻano he mea hoʻopili PROTAC e pili ana i nā kaulahao alkyl no ka synthesis o nā PROTAC.ʻO nā PROTAC nā mole e hiki ke hoʻoulu i ka hoʻohaʻahaʻa ʻana o nā protein target, e loaʻa ai nā hopena therapeutic ma o ka hoʻohaʻahaʻa ʻana i nā protein pili i ka maʻi.
Eia kekahi, hāʻawi nā hui biotechnology ʻoihana, e like me Shanghai Jinpan Biotechnology Co., Ltd., i kēia ʻano hui e kākoʻo i ka hana noiʻi o ka ʻepekema ola a me nā mea noiʻi lāʻau lapaʻau.Ke nānā mau nei kēia mau hui i nā ala hōʻailona a me nā wahi noiʻi maʻi, e hāʻawi ana i nā mea noiʻi me nā moleke bioactive kiʻekiʻe, nā mea hoʻopaneʻe, nā agonists, nā mea paʻa kikoʻī, nā hale waihona puke, a me nā protein recombinant.
Lys(Fmoc)-OH | H-Lys(Ac)-OH | Ac-Lys-OH | Fmoc-L-Lys-OH·HCl |
Cbz-L-Lys-OH | Fmoc-Lys-Ome·HCl | Fmoc-L-Lys(Boc)-OH | Fmoc-L-Lys(Fmoc)-OH |
Z-DL-Lys(cbz)-OH | Cbz-L-Lys(Fmoc)-OH |
1. No ka MOQ: Hiki iā mākou ke hoʻololi e like me kāu koi.
2. E pili ana i ka hāpana: Pono ka hāpana i ka uku hōʻailona, hiki ke lawe i ka ukana e hōʻiliʻili aiʻole hiki iāʻoe ke uku iā mākou ma mua.
3. Mold workshop, hiki ke hoʻopilikino ʻia e like me ka helu o nā hiʻohiʻona.
4. Hāʻawi mākou i ka lawelawe maikaʻi loa.Ke hana nei kekahi hui kūʻai akamai iā ʻoe.
5. E pili ana i ka hoʻololi: E ʻoluʻolu e leka uila a kamaʻilio mai iaʻu ma kou ʻoluʻolu.