171596-29-5 Tadalafil

ʻO Tadalafil, me ka molecular formula C22H19N3O4 a me ka molecular weight 389.4, i hoʻohana nui ʻia e mālama i ka erectile dysfunction i nā kāne mai 2003 ma lalo o ka inoa kālepa Cialis.Ma 2008, kūʻai aku ʻo Eli Lilly Company i nā kuleana hoʻomohala pāʻoihana no ka mālama PAH i United Therapeutics.I Iune 2009, ua ʻae ka FDA iā Tadafil no ka mālama ʻana i nā maʻi me ka pulmonary arterial hypertension (PAH) ma United States ma lalo o ka inoa kālepa Adcirca.Ua hoʻokumuʻiaʻo Tadafil ma 2003 ma keʻano he lāʻau lapaʻau no ka mālamaʻana iā ED, a ua maikaʻi ka hopena i ka 30min ma hope o ka hoʻoponoponoʻana, akāʻo ka hopena maikaʻi loaʻo 2h ma hope o ka hoʻoponoponoʻana, a hiki i ka hopena ke hoʻopau i ka 36h, aʻaʻole i pili ka hopena i ka meaʻai.ʻO ka nui o ka tadafil he 10 a i ʻole 20mg, ʻo ka mea i manaʻo ʻia he 10mg, ma muli o ka hopena o ka mea maʻi a me nā hopena ʻino.Ua hōʻike ʻia nā haʻawina ma mua o ka mākeke ma hope o 12 mau pule o ka lawelawe waha o 10 a i ʻole 20mg o tadafil, ʻo 67% a me 81% nā pane pane.Ua hōʻike nā haʻawina he nui ka maikaʻi o ka tadafil i ka mālama ʻana iā ED.
Erectile dysfunction: ʻO Tadanafil a me sildenafil ka mea like phosphodiesterase type 5 (PDE5), akā ʻokoʻa ko lākou ʻano i ka mea hope, a ʻaʻole e hoʻopilikia ka meaʻai momona i ko lākou absorption.Ma lalo o ka hoʻoulu ʻana i ka wahine, ʻo ka nitric oxide synthase (NOS) i loko o ka penile nerve endings a me nā cell endothelial vascular e hoʻopaʻa i ka synthesis o ka nitric oxide (NO) mai ka substrate L-arginine.NO ka ho'āla i ka guanylate cyclase, ka mea e hoʻohuli i ka guanosine triphosphate i cyclic guanosine phosphate (cGMP), a laila e hoʻoulu ai i ka cyclic guanosine phospho-dependent protein kinase, ka hopena i ka emi ʻana o ka calcium intracellular o ka ʻiʻo maʻemaʻe. ʻōhuʻu a me ke kūkulu ʻana.Hoʻohaʻahaʻa ka Phosphodiesterase type 5 (PDE5) i ka cGMP i nā huahana hana ʻole, me ka nāwaliwali o ka penile.Ma ke kāohiʻana i ka hoʻohaʻahaʻaʻana o PDE5, ke alakaʻi nei ka tardanafil i ka hōʻiliʻili o cGMP, kahi e hoʻomaha ai i kaʻiʻo maʻemaʻe o ka corpus cavernosum o ka penis a alakaʻi i ka penile.No ka mea ʻaʻohe mea hāʻawi kālā nitrate, hiki i kā lākou hui pū ʻana me tadanafil ke hoʻonui nui i ka pae cGMP a alakaʻi i ka hypotension koʻikoʻi, no laila, contraindicated nā contraindications clinical o nā mea ʻelua.
Hoʻopili ʻo Tardanafil i kēia ma ke kāohi ʻana i ka PDES.Hoʻohaʻahaʻa ka GMP, no laila ke hoʻohana pū ʻia me ka waikawa nitric a me ka vīneka hiki ke hoʻohaʻahaʻa loa i ke kahe koko a hoʻonui i ka pilikia o ka syncope.Hiki i ka CY3PA4 induction agent ke hoʻemi i ka loaʻa ʻana o ka abiotic o tadana, a ʻo ka hui pū ʻana me rifampicin, cimetidine, erythromycin, clarithromycin, itraconwa, ketoconwa a me HVI protease inhibitors hiki ke hoʻonui i ke koko o kēia huahana.Pono e noʻonoʻo i ka hoʻoponopono ʻana i ka dosage.I kēia manawa, ʻaʻohe hōʻike e pili ana i nā ʻāpana pharmacokinetic o kēia huahana i hoʻopilikia ʻia e ka meaʻai a me ka waiʻona.
Ke hoʻohana nei i ka D-tryptophan ma ke ʻano he mea maka, ʻo ka hopena methyl ester mua, ka hopena D-tryptophan methyl ester hydrochloride i loko o ka waiʻona isopropyl a me ka piperaldehyde Pictet-spengler reaction e kiʻi ai i ka cis-tetra hydrocarboline pūhui, a laila pane me ka chloroacetyl chloride a me methylamine, ka huina. ʻO 56% ka hua, ma hope o ka nānā ʻana, ua hoʻomaʻemaʻe hou ʻia ka waikawa acetic Glacial ma ke ʻano he mea hoʻoheheʻe recrystallization.Penei ka hoohalike pane kiko'ī:

ʻO Cialis ʻo Tadalafil, kahi lāʻau lapaʻau waha i hoʻomohala ʻia e Eli Lilly Pharmaceutical Company no ka mālama ʻana i ka erectile dysfunction i nā kāne.ʻO ia ka lua o ka hanauna phosphodiesterase 5 inhibitor.Hōʻike nā hōʻike noiʻi e hoʻohālikelike ʻia me ka sildenafil, ʻoi aku ka wikiwiki o Cialis, ma kahi o 15 a 20 mau minuke, a hiki i ka 36 mau hola.ʻO T1/2 he 17.5 hola.Ma kahi noiʻi o nā kāne 348 me ka maʻi ʻeha a me ka maʻi erectile koʻikoʻi i koho ʻia e lawe i ka tadalafil 20mg a i ʻole kahi placebo, ʻo 24 a me 36 mau hola ma hope o ka lawe ʻana i ka lāʻau i hoʻomaikaʻi i ka kūleʻa o ka moekolohe i hoʻohālikelike ʻia me ka placebo, me ka hapa nui o nā kāne i kūleʻa i ka moe ʻelua i nā hola 36.ʻAʻohe ʻokoʻa i ka hanana a me ka paʻakikī o nā hopena lāʻau ʻino i hoʻohālikelike ʻia me ka placebo.ʻOi aku ma mua o 5% o nā kāne ma ka hui ʻo Tadalafil i loaʻa i ke poʻo a me ka ʻeha.[Nā hopena maikaʻi ʻole] ʻAʻohe hopena ʻino koʻikoʻi i ʻike ʻia, e like me ka ʻili ʻana a me ka ʻike ʻana.I kekahi manawa ke poʻo, dyspepsia.ʻAʻole pono e ʻae ʻia nā poʻe maʻi e lawe ana i ka nitrates, angina pectoris, ka maʻi puʻuwai, ke kiʻekiʻe kiʻekiʻe ʻole a i ʻole hypotension, a me nā poʻe maʻi i loaʻa i ka hahau i nā mahina 6 i hala.

Hoʻohana ʻia ka Phosphodiesterase 5 inhibitors e mālama i ka erectile dysfunction i nā kāne.Hoʻohana ʻia ka lua o ka hanauna phosphodiesterase 5 inhibitors e mālama i ka erectile dysfunction i nā kāne.