NUI
No nā nīnau e pili ana i kā mākou huahana a i ʻole ka papa inoa kumukūʻai, e ʻoluʻolu e waiho i kāu leka uila iā mākou a e hoʻopili mākou i loko o 24 mau hola.
NINAU ANOKūlana halihali
Hiki i ka wela maʻamau
Manaʻo i ke ʻano hoʻouna
Ma ka lewa Ma ka aina Ma ke kai
Kūlana mālama:
E mālama i kahi pōʻeleʻele, Inert ea, lumi wela
Ola ola
Ma kahi o 2 makahiki
Ka nui o ke kauoha liʻiliʻi:
1kg (kūkākūkā)
palapala hōʻoia:COA, wahi hehee, Hoʻololi kikoʻī [α]D20
E hoʻouna mākou i nā ʻikepili āu e makemake ai.Hiki iā ʻoe ke ʻike i ka ʻikepili ma mua ma ke ʻano he kuhikuhi.
No nā huahana maʻamau, hoʻouna mākou i ka ʻikepili hou ma hope o ka puka ʻana mai.
Fmoc-N-methyl-O-methyl-D-tyrosine;
Fmoc-D-MePhe(4-OMe)-OH;
(2R)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}(methyl)amino)-3-(4-methoxyphenyl)propanoicacid;
(R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)-3-(4-methoxyphenyl)propanoicacid;
Fmoc-N-Me-D-Phe(4-OMe)-OH;
D-Tyrosine,N-[(9H-fluoren-9-ylmethoxy)carbonyl]-N,O-dimethyl-
Hoʻohana pinepine ʻia lākou no ka hoʻopili ʻana i ka pauka.Pili ia i nā koi o nā mea kūʻai aku.No laila, e haʻi mai iā mākou i kāu koi ma mua o ka hoʻopaʻa ʻana inā loaʻa iā ʻoe nā noi kūikawā.
1kg a 25kg He paʻakikī ka paʻi waho.A he mea paʻakikī ke ʻoki a hōʻino.Hiki iā ia ke pale pono i kāu mau huahana.
ʻO FMOC-N-Me-D-Tyr(Me)-OH, i ʻike ʻia ʻo N-α-(9-fluorenylmethoxycarbonyl)-N-α-methyl-D-tyrosine(3-methyl ester), he ʻakika amino derivative maʻamau. hoʻohana ʻia i ka peptide synthesis, ʻoi loa i ka solid-phase peptide synthesis.No ka ʻohana o FMOC (fluorenylmethoxycarbonyl) i pale ʻia nā amino acids, i hoʻohana nui ʻia i ka kemika peptide ma muli o ko lākou kūpaʻa a me ka maʻalahi o ka hoʻohana.
ʻO ka hui FMOC he hui pale no ka amino terminal o ka amino acid, e pale ana i nā hopena i makemake ʻole ʻia i ka wā o ka synthesis.Hāʻawi ka methyl ester ma ke kaulahao ʻaoʻao tyrosine i kahi pae hou o ka pale, hoʻopaʻa i ka pūhui a hōʻoia i kona maʻemaʻe i ka wā mālama a mālama ʻia.
ʻO ka noi mua o FMOC-N-Me-D-Tyr(Me)-OH i ka hoʻomākaukau ʻana i nā peptides a me nā protein.Ma ka hoʻokomo ʻana i kēia derivative amino acid i loko o ka synthesis, hiki i nā mea noiʻi ke hoʻohui i ka D-tyrosine me kahi hui methyl ma kāna kaulahao ʻaoʻao i kā lākou peptide sequences.Hiki ke hoʻohana ʻia kēia no ke aʻo ʻana i nā waiwai ola o nā peptides i loaʻa nā waikawa amino kūlohelohe ʻole a i ʻole e hana i nā analogs peptide me nā hana biological i hoʻololi ʻia.
Ma waho aʻe o kona hoʻohana ʻana i ka peptide synthesis, hiki i ka FMOC-N-Me-D-Tyr(Me)-OH ke loaʻa i nā noi ma nā ʻano ʻē aʻe o ka biochemistry a me ka biotechnology, e like me ka hoʻomohala ʻana i nā lāʻau lapaʻau hou a i ʻole nā mea lapaʻau.
N-Me-Tyr(Me)-OH.HCl | Boc-N-Me-L-Tyr(tbu)-OH | Fmoc-N-Me-L-Tyr(tBu)-OH | Cbz-N-Me-Tyr(tbu)-OH |
Fmoc-N-Me-D-Tyr(tBu)-OH | Boc-N-Me-L-Tyr(bzl)-OH | Fmoc-N-Me-L-Tyr(bzl)-OH | Boc-N-Me-D-Tyr(bzl)-OH |
1. No ka MOQ: Hiki iā mākou ke hoʻololi e like me kāu koi.
2. E pili ana i ka hāpana: Pono ka hāpana i ka uku hōʻailona, hiki ke lawe i ka ukana e hōʻiliʻili aiʻole hiki iāʻoe ke uku iā mākou ma mua.
3. Mold workshop, hiki ke hoʻopilikino ʻia e like me ka helu o nā hiʻohiʻona.
4. Hāʻawi mākou i ka lawelawe maikaʻi loa.Ke hana nei kekahi hui kūʻai akamai iā ʻoe.
5. E pili ana i ka hoʻololi: E ʻoluʻolu e leka uila a kamaʻilio mai iaʻu ma kou ʻoluʻolu.