200937-17-3 Boc-D-Leu-OH•H2O

Biochemistry a me ka ʻike lāʻau lapaʻau:
Ma ke ʻano he amino acid derivative, he kuleana koʻikoʻi ʻo Boc-D-Leu-OH·H2O i ka synthesizing peptides a me nā protein.Hiki i nā hoʻololi kemika o kēia pūhui ke alakaʻi i ka hoʻomohala ʻana i nā lāʻau lapaʻau hou a i ʻole nā ​​moho lāʻau lapaʻau no ka mālama ʻana i nā maʻi like ʻole.Hiki i nā waiwai kūʻokoʻa o D-leucine ke hāʻawi i nā hana olaola kūikawā i nā peptides synthesized a i ʻole nā ​​protein.
ʻO ka peptide Synthesis:
I loko o ka peptide synthesis solid-phase, ʻo Boc-D-Leu-OH·H2O kahi monomer amino acid nui.ʻO kāna pūʻulu pale Boc N-terminal e ʻae i ka ligation amino acid a me ka deprotection ma lalo o nā kūlana haʻahaʻa, e hiki ai i ka synthesis o nā kaulahao peptide me nā ʻano kikoʻī a me nā hana.
ʻImi ʻimi noiʻi:
Hoʻohana maʻamau ʻia ʻo Boc-D-Leu-OH·H2O i ka hana peptide synthesis a me nā haʻawina hoʻolālā protein.Ma ka hui pū ʻana me nā monomers amino acid ʻē aʻe, hiki ke hoʻohui ʻia nā ʻano peptide like ʻole e noiʻi i ka pilina protein-protein a me ka protein-ligand, a me ka hana protein a me nā hana hoʻoponopono.
Peptide Reagents a me Synthetic Auxiliaries:
Hiki i ka Boc-D-Leu-OH·H2O ke lawelawe ma ke ʻano he mea pale a i ʻole condensing condensing i ka peptide synthesis, e hoʻomaikaʻi ana i ka pono a me ka maʻemaʻe o ke kaʻina hana peptide synthesis.Hoʻohui ʻia, hiki ke hoʻohana ʻia ma ke ʻano he peptide reagent no ka lepili peptide, hoʻololi, a me ka ʻike.
Asymmetric Synthesis:
Ma muli o ke ʻano chiral o D-leucine, loaʻa iā Boc-D-Leu-OH·H2O nā noi kūpono i ka synthesis asymmetric.Ma ka hui pū ʻana me nā molekole chiral ʻē aʻe, hiki ke hoʻohui ʻia nā peptides a me nā protein me nā stereoconfigurations kikoʻī e aʻo i ka hopena o ka chirality i nā hana olaola.