NUI
No nā nīnau e pili ana i kā mākou huahana a i ʻole ka papa inoa kumukūʻai, e ʻoluʻolu e waiho i kāu leka uila iā mākou a e hoʻopili mākou i loko o 24 mau hola.
NINAU ANOKūlana halihali
Hiki i ka wela maʻamau
Manaʻo i ke ʻano hoʻouna
Ma ka lewa Ma ka aina Ma ke kai
Kūlana mālama:
E mālama i kahi pōʻeleʻele, Inert ea, lumi wela
ola mālama
Ma kahi o 2 makahiki
Ka nui o ke kauoha liʻiliʻi:
1kg (kūkākūkā)
palapala hōʻoia:COA, wahi hehee, Hoʻololi kikoʻī [α]D20
E hoʻouna mākou i nā ʻikepili āu e makemake ai.Hiki iā ʻoe ke ʻike i ka ʻikepili ma mua ma ke ʻano he kuhikuhi.
No nā huahana maʻamau, hoʻouna mākou i ka ʻikepili hou ma hope o ka puka ʻana mai.
BENZYLOXYCARBONYL-N-METHYL-L-ALANINE;
N-Benzyloxycarbonyl-N-methyl-L-alanine;
2- [benzyloxycarbonyl(methyl)amino]propionicacid;
2- [methyl(phenylmethoxycarbonyl)amino]propanoicacid;
ZL-MEALA-OH;
Z-MEALA-OH;
Z-METHYL-L-ALANINE;
ZN-ME-ALANINE
Hoʻohana pinepine ʻia lākou no ka hoʻopili ʻana i ka pauka.Pili ia i nā koi o nā mea kūʻai aku.No laila, e haʻi mai iā mākou i kāu koi ma mua o ka hoʻopaʻa ʻana inā loaʻa iā ʻoe nā noi kūikawā.
1kg a 25kg He paʻakikī ka paʻi waho.A he mea paʻakikī ke ʻoki a hōʻino.Hiki iā ia ke pale pono i kāu mau huahana.
Peptide Synthesis: ʻO Cbz-N-Me-L-Ala-OH ka mea hana ma ke ʻano he hale kūkulu hale i loko o ka peptide synthesis solid-phase.Hoʻopaʻa ka hui pale benzoxycarbonyl (Cbz) i ka pūʻulu amino o ka waikawa amino i ka wā o ke kaʻina synthesis, e hōʻoia ana i nā hopena kikoʻī a maikaʻi.Hoʻololi ka N-methylation i nā waiwai kemika o ka alanine, a laila e hoʻololi i nā waiwai āpau a me nā hana o nā peptides hopena.
ʻIke a me ka hoʻomohala ʻana i ka lāʻau lapaʻau: Cbz-N-Me-L-Ala-OH a me kāna peptide conjugates e hana nui i ka hoʻolālā a me ka hoʻomohala ʻana i ka lāʻau.Ma muli o kā lākou mau hana kemika kūʻokoʻa, hiki iā lākou ke hōʻike i nā hana lāʻau lapaʻau kikoʻī, e hana ana iā lākou i mea hoʻopale enzyme, nā ligand receptor, a i ʻole nā molekole transduction hōʻailona.Wehe kēia i nā manawa no ka hoʻomohala ʻana i nā therapeutics hou a i ʻole ka hoʻokō ʻana i ka hana o nā lāʻau lapaʻau.
Nā Haʻawina Hana Ola: ʻO ka hoʻokomo ʻana i ka N-methylation ma Cbz-N-Me-L-Ala-OH e hoʻololi i ka hana olaola o ka alanine, e hoʻololi ana i nā pilina ma waena o nā peptides a me nā biomolecules e like me nā protein, nā enzymes, a i ʻole nā mea hoʻokipa.Hoʻolilo kēia iā Cbz-N-Me-L-Ala-OH i mea hana ikaika no ke aʻo ʻana i nā hana olaola, nā hana protein, a me nā ala transduction hōʻailona.
Noiʻi Biology Structural: Hiki ke hoʻohana ʻia ʻo Cbz-N-Me-L-Ala-OH i ka noiʻi biology structural no ka noiʻi ʻana i ka conformation, kūpaʻa, a me ka launa pū ʻana o nā peptides me nā molekala olaola ʻē aʻe.He mea koʻikoʻi kēia ʻike no ka hoʻomaopopo ʻana i nā kaʻina hana olaola, nā mīkini maʻi, a me nā ʻano hana lāʻau.
L-ALa | DL-ALA | D-ALa | HN-Me-L-Ala-OH |
N-Me-L-Ala-OMe | N-Me-L-Ala-Ome.Hcl | Boc-N-Me-Ala-OH | Boc-N-Me-DL-Ala-OH |
Fmoc-LN-Me-Ala-OH | Fmoc-N-Me-D-Ala-OH | Cbz-N-Me-D-Ala-OH | HN-Me-L-Ala-OH |
1. No ka MOQ: Hiki iā mākou ke hoʻololi e like me kāu koi.
2. E pili ana i ka hāpana: Pono ka hāpana i ka uku hōʻailona, hiki ke lawe i ka ukana e hōʻiliʻili aiʻole hiki iāʻoe ke uku iā mākou ma mua.
3. Mold workshop, hiki ke hoʻopilikino ʻia e like me ka helu o nā hiʻohiʻona.
4. Hāʻawi mākou i ka lawelawe maikaʻi loa.Ke hana nei kekahi hui kūʻai akamai iā ʻoe.
5. E pili ana i ka hoʻololi: E ʻoluʻolu e leka uila a kamaʻilio mai iaʻu ma kou ʻoluʻolu.