22254-24-6 8-Isopropylatropinium bromide

ʻIke ʻia ʻo Ipratropium bromide ʻo Haizhupanidine, isopropyl atropine, isopropyl scopolamine, isopropyl atropine, ipratropine bromide, isopropyl atropine bromide, ipratropine bromide, ipratropium bromide, a me ipratropium bromide.He pauda kristal keʻokeʻo me ka ʻono ʻawaʻawa.Ka helu hehee 232 ℃-233 ℃.Hiki ke hoʻoheheʻe ʻia i ka wai, hiki ke hoʻoheheʻe ʻia i loko o ka ethanol, ʻaʻole hiki ke hoʻoheheʻe ʻia i loko o nā mea hoʻoheheʻe organik ʻē aʻe.Ka inoa kemika: Brominated α-(hydroxymethyl) -phenylacetic acid - 8-methyl-8-isopropyl - azocyclic [3,2,1] -3-octyl ester.He lāʻau anticholinergic ia, he hopena hoʻomaha ikaika i ka ʻiʻo maʻemaʻe bronchial a me ka hopena antiasthmatic i ka maʻi pulmonary obstructive maʻi.ʻIke ʻia kona hopena, hopena wikiwiki a lōʻihi ka lōʻihi.ʻO ka Ipratropium bromide hoʻi e hoʻomalu i ka huna ʻana o nā ʻōpala mucus a hoʻomaikaʻi i ka neʻe ʻana o ka ciliary, no laila e hōʻemi ai i ka pale ʻana i ka sputum e hoʻomaikaʻi i ka ea.Eia naʻe, ʻo ka emi ʻana o ka sputum e hōʻoluʻolu i ka bronchospasm ma muli o ka huhū bronchial.No ka pale ʻana a me ka mālama ʻana i ka hānō bronchial a me ka bronchitis maʻi maʻi asthmatic, ʻoi aku hoʻi no nā poʻe maʻi ʻaʻole hiki ke ʻae i ka hoʻohana ʻana i ka β-agonist muscle haʻalulu, tachycardia.Hiki ke hoʻohana pū ʻia kēia huahana me nā beta-agonists e hoʻonui i ka pono o kekahi i kekahi, e like me ka hui pū me ka finoterol e hana i kahi aerosol (BERODU -- AL) no ka hānō, bronchitis mau a me ka emphysema.Ke hoʻohālikelike ʻia me nā mea hoʻonāuki β-adrenergic receptor (eg, isopropyl epinephrine), ʻoi aku ka liʻiliʻi o kēia huahana i nā hopena ʻaoʻao cardiovascular, a hoʻohālikelike ʻia me nā mea hoʻouluulu β2-receptor (eg, Suquanling), ʻoi aku ka ikaika o kēia huahana i ka hopena hoʻoponopono i ka nui o ka phlegm.
Kapu inhalation.40 ~ 80μg hoʻokahi, 2 ~ 4 mau manawa i ka lā.I ka hoʻohana ʻana, e wehe mua i ka pāpale uhi uhi, e kau i ka uhi uhi keʻa maka ma ka nozzle, e hoʻohuli i ka ʻōmole i lalo i lalo, e paʻa ka uhi uhi i ka waha, e kuhikuhi i ka ʻāʻī, e hoʻomoʻi i ke kinoea i ka manawa like, e kaomi i ka nozzle. ma ka valve, inhale i ka wai, paa i kou hanu no kekahi manawa.E hana hou i ka paʻi ma luna inā pono.Aerosol: 0.025% solution.Papa: 10mg/papa.
Hiki ke mālama ʻia ka lāʻau make anticholinergic koʻikoʻi me nā mea hoʻopaneʻe cholinesterase.
ʻO nā hopena maikaʻi ʻole o ka ipratropium bromide e like me ka atropine, hiki ke hoʻoulu i ka palpitation, headache, dizziness, nervousness, nausea, luaʻi, ʻeha o ka ʻōpū, haʻalulu, ʻike makapō, waha maloʻo, ʻū, dysuria, aggravation o nā hōʻailona hanu a me ka ʻeha.
ʻO ka Ipratropium bromide he mea hakakā muscarinic, bronchodilator, a me ka paʻakai isopropyl o AtropineN.
Hoʻohui ʻia ʻo Ipratropiumbromide a me Formoterol no ka pale ʻana i nā māmā mai ka mumū mau a hoʻonui i ka māmā, e hōʻemi ana i nā neutrophils ma ke kāohi ʻana i ka hana ma o MMP-9.ʻO ka Ipratropiumbromide(1nM) i hoʻonui nui i ka calcium bromide, hoʻemi i ka hoʻopuehu ʻana i mua a hoʻonui i ka hoʻopaʻa ʻana i ka annexin-V.Ma hope o ka mālama ʻana i ka Ipratropiumbromide, piʻi iki ka hemolysis akā nui.ʻO ka Ipratropiumbromide ke kumu o ka make o ke koko ʻulaʻula suicidal a i ʻole eryptosis, ma muli o ka hoʻoulu ʻana o ka calcium.
ʻO ka Ipratropium maloʻo maloʻo inhalation (DPI) he bronchodilator maikaʻi i ka hoʻomaha ʻana i nā lio ma kahi ʻano o 2400 mg / lio, me ka liʻiliʻi o ka hopena ma luna o ke ala ea kiʻekiʻe i ka wā hoʻōla.I nā ʻiole i mālama ʻia ma ka cadmium, ua hoʻemi nui ʻo Ipratropium i ke kahe ʻana o nā cell inflammatory parenchymal a ua ʻike ʻia nā maʻi ʻeha e pili ana.Mālama ʻo Ipratropium i ka ʻāmāmā mai ka hoʻohaʻahaʻa ʻana i ka neutrophil infiltration.I loko o ka guinea pig tracheal muscle smooth, Ipratropium is a antagonist that inhibits the prebound muscarinic inhibitory receptor of the lung parasympathetic nerve.Ua hōʻike pū ʻia ʻo Ipratropium i kahi antagonist ikaika ma hope o ka hoʻopaʻa ʻana i ka muscarinic inhibitory receptors.Hoʻemi ʻo Ipratropium i nā hoʻololi kiʻekiʻe loa o ke kaomi umauma a hoʻonui i ka hoʻokō ikaika (Cdyn) i ka hanu ʻana o ke kai (incremental Pplmax) a me ke kūpaʻa pulmonary (RL) i nā lio.