NUI
No nā nīnau e pili ana i kā mākou huahana a i ʻole ka papa inoa kumukūʻai, e ʻoluʻolu e waiho i kāu leka uila iā mākou a e hoʻopili mākou i loko o 24 mau hola.
NINAU ANOKūlana halihali
Hiki i ka wela maʻamau
Manaʻo i ke ʻano hoʻouna
Ma ka lewa Ma ka aina Ma ke kai
Kūlana mālama:
E mālama i kahi pōʻeleʻele, Inert ea, lumi wela
Ola ola
Ma kahi o 2 makahiki
Ka nui o ke kauoha liʻiliʻi:
1kg (kūkākūkā)
palapala hōʻoia:COA, wahi hehee, Hoʻololi kikoʻī [α]D20
E hoʻouna mākou i nā ʻikepili āu e makemake ai.Hiki iā ʻoe ke ʻike i ka ʻikepili ma mua ma ke ʻano he kuhikuhi.
No nā huahana maʻamau, hoʻouna mākou i ka ʻikepili hou ma hope o ka puka ʻana mai.
N-BOC-O-Benzyl-L-ser;
N-Boc-O-benzyl-L-serineBoc-Ser(Bzl)-OH;
(S)-3-(benzyloxy)-2-((tert-butoxycarbonyl)aMino)propanoicacid;
N-BOC-O-BENZYL-SERINE;
(2S)-3-Benzyloxy-2-(tert-butoxycarbonylamino)propanoicacid;
L-SERINE-NT-BOC,O-BZETHER(15N);
L-SERINE-NT-BOC,O-BZETHER(2-13C)
Hoʻohana pinepine ʻia lākou no ka pauka paʻa.Pili ia i nā koi o ka mea kūʻai.No laila, inā loaʻa iā ʻoe nā koi kūikawā, e ʻoluʻolu e hoʻomaopopo iā mākou i kāu mau koi ma mua o ka hoʻopili ʻana.
Paʻakikī loa ka pūʻolo o waho.A ʻaʻole maʻalahi ke ʻoki a hōʻino ʻia.Hiki iā ia ke pale pono i kāu mau huahana.
ʻO ka peptide Synthesis:
Hana ʻo Boc-Ser (Bzl) -OH ma ke ʻano he hale kūkulu hale i ka paʻa paʻa a i ʻole ka hopena-phase peptide synthesis.Hiki ke hui pū ʻia me nā ʻakika amino ʻē aʻe a i ʻole nā ʻāpana peptide e hana i nā peptides lōʻihi a i ʻole nā protein.
Mālama ka hui benzyl (Bzl) i ka pūʻulu hydroxyl o serine, e ʻae ana i nā hopena koho ma nā wahi ʻē aʻe i loko o ke kaulahao peptide.
Mālama ka hui Boc i ka pūʻulu amino, e pale ana i nā hopena ʻaoʻao makemake ʻole i ka wā o ka peptide synthesis.
Haʻawina Biochemical:
Hiki ke hoʻohana ʻia ʻo Boc-Ser(Bzl) -OH ma ke ʻano he reagent i nā hoʻokolohua biochemical e aʻo ai i ka pilina protein-protein, enzyme kinetics, a me nā noi biology molecular ʻē aʻe.
Ma ka hoʻokomo ʻana i kēia derivative amino acid i loko o nā peptides a i ʻole nā protein, hiki i nā mea noiʻi ke ʻimi i kā lākou hana a me ka launa pū ʻana me nā molekala olaola ʻē aʻe.
ʻIke lāʻau lapaʻau:
Hiki ke hoʻokomo ʻia ʻo Boc-Ser(Bzl) -OH i loko o nā peptidomimetics a i ʻole nā lāʻau peptide, i hoʻolālā ʻia e hoʻohālike i nā hana ola o nā peptides kūlohelohe.
Hiki i kēia mau peptidomimetics ke loaʻa i nā mea lapaʻau i nā wahi e like me ke kanesa, nā maʻi maʻi, a me nā maʻi neurological.
Hiki ke hoʻoneʻe ʻia ka hui benzyl i ka wā o ka hoʻomohala ʻana i ka lāʻau lapaʻau e hōʻike i ka pūʻulu hydroxyl manuahi o ka serine, pono paha ia no ka hana olaola o ka peptide.
ʻepekema Material:
Hiki ke hoʻohana ʻia ʻo Boc-Ser (Bzl) -OH i ka synthesis o nā polymers biocompatible a biodegradable no ka ʻenekinia kiko, ka lawe ʻana i ka lāʻau lapaʻau, a me nā noi biomedical ʻē aʻe.
Hiki ke hoʻolālā ʻia kēia mau polymers e hoʻokuʻu i nā lāʻau lapaʻau a i ʻole nā molekele bioactive ma ke ʻano i hoʻomalu ʻia, e hoʻomaikaʻi ana i kā lākou therapeutic efficacy a hōʻemi i nā hopena ʻaoʻao.
L-Ser | H-DL-Ser-OH | D-Ser(tBu)-OH |
D-Ser(bzl) | D-Ser(bzl).HCl | HL-Ser(Bzl)-OH.HCl |
HL-Ser(Bzl)-OH | HL-Ser(Bzl)-OL.HCl | HL-Ser-OBzl.HCl |
HL-Ser-OBzl | DL-Ser-Obzl.Hcl | D-Ser-Obzl.Hcl |
HL-Ser(Bzl)-OMe·HCl | Boc-L-Ser-OH | Boc-L-Ser.H2O |
Boc-DL-Ser-OH | Boc-D-Ser-OH | Boc-L-ser(me)-OH |
Boc-L-ser(me).DCHA | Boc-DL-Ser(me)-OH | Boc-D-ser(me)-OH |
Boc-L-Ser(tBu)-OH | Boc-D-Ser(tBu)-OH | Boc-D-Ser(Tbu).DCHA |
Boc-L-Ser(Bzl)-OH | Boc-DL-Ser(Bzl)-OH | Boc-D-Ser(Bzl)-OH |
Boc-Ser(Bzl)-ol | Boc-D-Ser(Bzl)-OL | Boc-L-Ser-OMe |
Boc-DL-Ser-Ome | Boc-D-Ser-OMe | Boc-D-Ser-Oet |
Boc-L-Ser-Obzl | Boc-D-Ser-Obzl | Boc-L-Ser(bzl)-OSu |
Fmoc-L-Ser(bzl)-OH | Fmoc-D-Ser(bzl)-OH | Fmoc-L-Ser-Obzl |
Fmoc-N-Me-Ser(bzl) | ZL-Ser(Bzl)-OH | Cbz-D-Ser(Bzl)-OH |
Cbz-L-Ser-Obzl |
1. E pili ana i ke kumu kūʻai: hiki ke kūkākūkā ke kumukūʻai.Hiki iā mākou ke hoʻololi e like me kāu nui.
2. No OEM: Hiki iā ʻoe ke hoʻouna i kāu hoʻolālā ponoʻī a me ka logo.Hiki iā mākou ke wehe i ka mold hou a me ka logo, a laila e hoʻouna i ka hāpana no ka hōʻoia.
3. E pili ana i ka hoʻololi: E ʻoluʻolu e leka uila a kamaʻilio paha iaʻu ma kou ʻoluʻolu.
4. Kiʻekiʻe kiʻekiʻe: ʻO ka hoʻohana ʻana i nā mea kiʻekiʻe kiʻekiʻe, ka hoʻokumu ʻana i ka ʻōnaehana mana koʻikoʻi, nā limahana i koho ʻia ke kuleana no kēlā me kēia kaʻina hana mai ke kūʻai ʻana i nā mea waiwai a hiki i ka hoʻopili.