NUI
No nā nīnau e pili ana i kā mākou huahana a i ʻole ka papa inoa kumukūʻai, e ʻoluʻolu e waiho i kāu leka uila iā mākou a e hoʻopili mākou i loko o 24 mau hola.
NINAU ANOKūlana halihali
Hiki i ka wela maʻamau
Manaʻo i ke ʻano hoʻouna
Ma ka lewa Ma ka aina Ma ke kai
Kūlana mālama:
E mālama i kahi pōʻeleʻele, Inert ea, lumi wela
ola mālama
Ma kahi o 2 makahiki
Ka nui o ke kauoha liʻiliʻi:
1kg (kūkākūkā)
palapala hōʻoia:COA, wahi hehee, Hoʻololi kikoʻī [α]D20
E hoʻouna mākou i nā ʻikepili āu e makemake ai.Hiki iā ʻoe ke ʻike i ka ʻikepili ma mua ma ke ʻano he kuhikuhi.
No nā huahana maʻamau, hoʻouna mākou i ka ʻikepili hou ma hope o ka puka ʻana mai.
FMoc-N-Methyl-DL-valine;
Valine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-N-methyl-;
Fmoc-N-Me-DL-Val-OH
Hoʻohana pinepine ʻia lākou no ka hoʻopili ʻana i ka pauka.Pili ia i nā koi o nā mea kūʻai aku.No laila, e haʻi mai iā mākou i kāu koi ma mua o ka hoʻopaʻa ʻana inā loaʻa iā ʻoe nā noi kūikawā.
1kg a 25kg He paʻakikī ka paʻi waho.A he mea paʻakikī ke ʻoki a hōʻino.Hiki iā ia ke pale pono i kāu mau huahana.
Peptide Synthesis: I loko o ka peptide synthesis solid-phase, lawelawe ʻo Fmoc-N-Me-DL-Val-OH i koena amino acid no ka hoʻokomo ʻana i nā kaulahao peptide.Hoʻonui kāna N-methylation i ka paʻa a me ka solubility i ka wā o ka peptide synthesis, e hoʻomaʻamaʻa i ka hana ʻana o nā peptides i hoʻomaʻemaʻe kiʻekiʻe.
Noiʻi Biochemical: He kuleana koʻikoʻi nā Peptides i nā ʻōnaehana olaola, e like me nā hormones, enzymes, a me nā antibodies.No laila, koʻikoʻi ka peptide synthesis i ka noiʻi biochemical.ʻO ka hoʻokomo ʻana o Fmoc-N-Me-DL-Val-OH e hiki ai i nā mea noiʻi ke hoʻohālikelike pololei a noiʻi paha i nā hana ola o nā peptides kikoʻī.
Hoʻolālā a me ka hoʻomohala ʻana i ka lāʻau lapaʻau: Ke puka mai nei nā lāʻau lapaʻau i hoʻokumu ʻia i ka peptide ma ke ʻano he kuhikuhi koʻikoʻi i ka ʻike ʻana i ka lāʻau ma muli o ko lākou kikoʻī kiʻekiʻe a me ka haʻahaʻa haʻahaʻa.Ma ke ʻano he kumu waiwai nui i ka peptide synthesis, hāʻawi ʻo Fmoc-N-Me-DL-Val-OH i nā mea hou aku no ka hoʻolālā lāʻau a me ka hoʻomohala ʻana.
L-Val-OH | DL-Val | HD-Val-OH | N-Me-L-Val-OH |
N-Me-L-Val.HCl | N-Me-D-Val | N-Me-D-Val-OH·HCl | N-Me-L-Val-Ome.HCl |
N-Me-D-Val-Ome.HCl | N-Me-Val-Obzl.HCl | N-Me-D-Val-Obzl.HCl | N-Me-Val-Obzl.Tos |
Boc-N-Me-Val-OH | Boc-N-Me-D-Val-OH | Fmoc-N-Me-Val-OH | Cbz-N-Me-D-Val-OH |
Fmoc-N-Me-D-Val-OH | Cbz-N-Me-L-Val-OH |
1. No ka MOQ: Hiki iā mākou ke hoʻololi e like me kāu koi.
2. E pili ana i ka hāpana: Pono ka hāpana i ka uku hōʻailona, hiki ke lawe i ka ukana e hōʻiliʻili aiʻole hiki iāʻoe ke uku iā mākou ma mua.
3. Mold workshop, hiki ke hoʻopilikino ʻia e like me ka helu o nā hiʻohiʻona.
4. Hāʻawi mākou i ka lawelawe maikaʻi loa.Ke hana nei kekahi hui kūʻai akamai iā ʻoe.
5. E pili ana i ka hoʻololi: E ʻoluʻolu e leka uila a kamaʻilio mai iaʻu ma kou ʻoluʻolu.