NUI
No nā nīnau e pili ana i kā mākou huahana a i ʻole ka papa inoa kumukūʻai, e ʻoluʻolu e waiho i kāu leka uila iā mākou a e hoʻopili mākou i loko o 24 mau hola.
NINAU ANOKūlana halihali
Hiki i ka wela maʻamau
Manaʻo i ke ʻano hoʻouna
Ma ka lewa Ma ka aina Ma ke kai
Kūlana mālama:
E mālama i kahi pōʻeleʻele, Inert ea, lumi wela
Ola ola
Ma kahi o 2 makahiki
Ka nui o ke kauoha liʻiliʻi:
1kg (kūkākūkā)
palapala hōʻoia:COA, wahi hehee, Hoʻololi kikoʻī [α]D20
E hoʻouna mākou i nā ʻikepili āu e makemake ai.Hiki iā ʻoe ke ʻike i ka ʻikepili ma mua ma ke ʻano he kuhikuhi.
No nā huahana maʻamau, hoʻouna mākou i ka ʻikepili hou ma hope o ka puka ʻana mai.
BOC-N-ALPHA-METHYL-L-PHENYLGLYCINE;
BOC-MEPHG-OH;
BOC-N-METHYL-L-PHENYLGLYCINE;
BOC-N-ME-PHENYLGLYCINE;
BOC-N-ME-PHG-OH;
BOC-L-MEPHG-OH;
BOC-(PH)SAR-OH;
Boc-N-Methyl-(S)-2-phenylglycine
Hoʻohana pinepine ʻia lākou no ka hoʻopili ʻana i ka pauka.Pili ia i nā koi o nā mea kūʻai aku.No laila, e haʻi mai iā mākou i kāu koi ma mua o ka hoʻopaʻa ʻana inā loaʻa iā ʻoe nā noi kūikawā.
1kg a 25kg He paʻakikī ka paʻi waho.A he mea paʻakikī ke ʻoki a hōʻino.Hiki iā ia ke pale pono i kāu mau huahana.
ʻO ka peptide Synthesis:
Hoʻohana mau ʻia ʻo Boc-N-Me-L-Phg-OH ma ke ʻano he mea hoʻomaka a i ʻole pūʻulu pale i ka peptide synthesis.Hiki iā ia ke hana i nā hopena condensation me nā waikawa amino ʻē aʻe e hana i nā kaulahao peptide me nā ʻano kikoʻī a me nā hale.He mea pono loa kēia pūhui i loko o ka solid-phase peptide synthesis, kahi e pale ai i ka terminal amino, pale i nā hopena ʻaoʻao i makemake ʻole ʻia, a hoʻomaʻamaʻa i nā hoʻolālā kūpono a me nā hoʻolālā deprotection.
Ka noiʻi biochemical:
Hoʻohana ʻia ʻo Boc-N-Me-L-Phg-OH i nā noiʻi biochemical e noiʻi i ke ʻano a me ka hana o nā protein a i ʻole nā peptides.Ma ka hoʻokomoʻana i kēia waikawa amino i hoʻololiʻia, hiki i nā mea noiʻi ke aʻo i ka hopena o nā hoʻololi, e like me ka methylation, i ka hana olaola a me nā pilina o nā protein a iʻole nā peptides me nā moleke'ē aʻe.He mea koʻikoʻi kēia no ka hoʻomaopopo ʻana i nā ala hōʻailona, nā ala metabolic, a me nā mīkini maʻi i loko o nā ʻōnaehana olaola.
ʻIke lāʻau lapaʻau:
Hana ʻo Boc-N-Me-L-Phg-OH ma ke ʻano he mea hoʻomaka a waena paha i ka ʻike ʻana i ka lāʻau lapaʻau, e hāʻawi ana i ka synthesis o nā lāʻau peptide therapeutically active.Hiki i kēia mau lāʻau peptide ke hōʻike i ka antibacterial, antiviral, antitumor, anti-inflammatory, a me nā hana olaola ʻē aʻe, e hoʻolilo iā lākou i mea waiwai no ka mālama ʻana i nā maʻi like ʻole.Eia hou, hiki ke hoʻohana ʻia ʻo Boc-N-Me-L-Phg-OH i ka synthesis o nā hormones peptide, peptide antibiotics, a me nā peptides bioactive ʻē aʻe.
Nā noi ʻē aʻe:
Ma waho aʻe o nā hoʻohana i ʻōlelo ʻia ma luna, hiki ke hoʻohana ʻia ʻo Boc-N-Me-L-Phg-OH i ka hoʻomākaukau ʻana i nā biomaterials, nā mea ʻike kemika, a me nā catalysts.No ka laʻana, hiki iā ia ke hana me nā pūhui ʻē aʻe e hana i nā mea polymer me nā hana kikoʻī.Eia kekahi, hiki ke hoʻohana ʻia i ka hoʻomākaukau ʻana i nā catalysts chiral no ka synthesis asymmetric a me nā hopena ʻē aʻe.
Fmoc-N-Me-D-Phg-OH | Fmoc-N-Me-L-Phg-OH | Boc-N-Me-D-Phg-OH | Boc-N-Me-DL-Phg-OH |
1. No ka MOQ: Hiki iā mākou ke hoʻololi e like me kāu koi.
2. E pili ana i ka hāpana: Pono ka hāpana i ka uku hōʻailona, hiki ke lawe i ka ukana e hōʻiliʻili aiʻole hiki iāʻoe ke uku iā mākou ma mua.
3. Mold workshop, hiki ke hoʻopilikino ʻia e like me ka helu o nā hiʻohiʻona.
4. Hāʻawi mākou i ka lawelawe maikaʻi loa.Ke hana nei kekahi hui kūʻai akamai iā ʻoe.
5. E pili ana i ka hoʻololi: E ʻoluʻolu e leka uila a kamaʻilio mai iaʻu ma kou ʻoluʻolu.