NUI
No nā nīnau e pili ana i kā mākou huahana a i ʻole ka papa inoa kumukūʻai, e ʻoluʻolu e waiho i kāu leka uila iā mākou a e hoʻopili mākou i loko o 24 mau hola.
NINAU ANOKūlana halihali
Hiki i ka wela maʻamau
Manaʻo i ke ʻano hoʻouna
Ma ka lewa Ma ka aina Ma ke kai
Kūlana mālama:
E mālama i kahi pōʻeleʻele, Inert ea, lumi wela
ola mālama
Ma kahi o 2 makahiki
Ka nui o ke kauoha liʻiliʻi:
1kg (kūkākūkā)
palapala hōʻoia:COA, wahi hehee, Hoʻololi kikoʻī [α]D20
E hoʻouna mākou i nā ʻikepili āu e makemake ai.Hiki iā ʻoe ke ʻike i ka ʻikepili ma mua ma ke ʻano he kuhikuhi.
No nā huahana maʻamau, hoʻouna mākou i ka ʻikepili hou ma hope o ka puka ʻana mai.
Cbz-N-Me-L-Leu-OH;
ZN-methyl-L-leucine99%;
N-carbobenzyloxy-N-methyl-L-leucine;
(S)-2-((benzyloxycarbonyl)(methyl)amino)-4-methylpentanoicacid;
ZN-Me-L-Leu-OH;
(2S)-2-[[(benzyloxy)carbonyl](Methyl)aMino]-4-Methylpentanoicacid;
Cbz-N-Methyl-L-leucine;
4-methyl-2-[methyl(phenylmethoxycarbonyl)amino]pentanoicacid
Hoʻohana pinepine ʻia lākou no ka hoʻopili ʻana i ka pauka.Pili ia i nā koi o nā mea kūʻai aku.No laila, e haʻi mai iā mākou i kāu koi ma mua o ka hoʻopaʻa ʻana inā loaʻa iā ʻoe nā noi kūikawā.
1kg a 25kg He paʻakikī ka paʻi waho.A he mea paʻakikī ke ʻoki a hōʻino.Hiki iā ia ke pale pono i kāu mau huahana.
ʻO ka Peptide Synthesis: I ka synthesis o nā peptides a me nā protein, hoʻohana pinepine ʻia ʻo Cbz-N-Me-L-Leu-OH ma ke ʻano he hui pale.Ma ka hoʻokomo ʻana i kēia pūʻulu pale, ʻae ia i ka pale koho ʻana i nā kaulahao ʻaoʻao amino acid, no laila e pale aku ai i nā hopena ʻaoʻao pono ʻole i ka wā o ka elongation o ke kaulahao peptide.Hiki ke hoʻoneʻe ʻia kēia pūʻulu pale ma o nā ʻano kemika kūikawā ma hope o ka synthesis e loaʻa ai ka peptide target.
ʻO ka Hoʻolālā Lapaʻau a me ka Synthesis: Ma ka hoʻolālā lāʻau a me ka synthesis, hiki iā Cbz-N-Me-L-Leu-OH ke lilo i hale kūkulu hale no ka synthesizing pūhui me nā hana olaola kikoʻī.ʻO Leucine kahi amino acid non-polar e hana nui i nā peptides bioactive a me nā protein.ʻO ka hoʻokomo ʻana i nā hui pale methyl a me benzyloxycarbonyl hiki ke hoʻololi hou i nā waiwai physicochemical a me nā hana olaola o kēia mau pūhui.
Kūwaena i loko o Organic Synthesis: I ka organic synthesis, Cbz-N-Me-L-Leu-OH hiki ke hana ma ke 'ano he mea waena no ka ho'ohui 'ana i nā molekole organik pa'akikī.Ma ka pane ʻana me nā mea hoʻoheheʻe organik ʻē aʻe, hiki iā ia ke hana i nā pūhui organik me nā hale a me nā hana kikoʻī, hiki ke hoʻohana ʻia i ka ʻepekema waiwai, biology kemika, a me nā kula ʻē aʻe.
N-Me-L-Leu | N-me-D-leu-obzl | Boc-N-Me-L-Leu-OH | Fmoc-N-Me-D-Leu-OH |
Fmoc-LN-Me-Leu-OH | Boc-N-Me-D-Leu-OH | Cbz-N-Me-D-Leu-OH |
1. No ka MOQ: Hiki iā mākou ke hoʻololi e like me kāu koi.
2. E pili ana i ka hāpana: Pono ka hāpana i ka uku hōʻailona, hiki ke lawe i ka ukana e hōʻiliʻili aiʻole hiki iāʻoe ke uku iā mākou ma mua.
3. Mold workshop, hiki ke hoʻopilikino ʻia e like me ka helu o nā hiʻohiʻona.
4. Hāʻawi mākou i ka lawelawe maikaʻi loa.Ke hana nei kekahi hui kūʻai akamai iā ʻoe.
5. E pili ana i ka hoʻololi: E ʻoluʻolu e leka uila a kamaʻilio mai iaʻu ma kou ʻoluʻolu.