NUI
No nā nīnau e pili ana i kā mākou huahana a i ʻole ka papa inoa kumukūʻai, e ʻoluʻolu e waiho i kāu leka uila iā mākou a e hoʻopili mākou i loko o 24 mau hola.
NINAU ANOKūlana halihali
Hiki i ka wela maʻamau
Manaʻo i ke ʻano hoʻouna
Ma ka lewa Ma ka aina Ma ke kai
Kūlana mālama:
E mālama i kahi pōʻeleʻele, Inert ea, lumi wela
Ola ola
Ma kahi o 2 makahiki
Ka nui o ke kauoha liʻiliʻi:
1kg (kūkākūkā)
palapala hōʻoia:COA, wahi hehee, Hoʻololi kikoʻī [α]D20
E hoʻouna mākou i nā ʻikepili āu e makemake ai.Hiki iā ʻoe ke ʻike i ka ʻikepili ma mua ma ke ʻano he kuhikuhi.
No nā huahana maʻamau, hoʻouna mākou i ka ʻikepili hou ma hope o ka puka ʻana mai.
(2S)-2-(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)pentanedioicacid;
n-phthalyl-l-glutamicacid;
N-PHTHALIMIDEL-GLUTAMINCACID;
N-PHTHALOYL-L-GLUTAMICACID;
PTHALYL-L-GLUTAMICACID;
PHTHALOYL-L-GLUTAMICACID;
PHT-GLU-OH;
PHGA
Hoʻohana pinepine ʻia lākou no ka hoʻopili ʻana i ka pauka.Pili ia i nā koi o nā mea kūʻai aku.No laila, e haʻi mai iā mākou i kāu koi ma mua o ka hoʻopaʻa ʻana inā loaʻa iā ʻoe nā noi kūikawā.
1kg a 25kg He paʻakikī ka paʻi waho.A he mea paʻakikī ke ʻoki a hōʻino.Hiki iā ia ke pale pono i kāu mau huahana.
Hiki ke hoʻohana ʻia ka PTHHALYL-L-GLUTAMIC ACID e hana (R)-(+)-THALIDOMIDE.He glutamic acid derivative me ka hopena therapeutic ʻole i ka maʻi lepera, a hoʻohana pū ʻia me nā lāʻau antileprosy e hōʻemi i ka hopena o ka maʻi lepera a mālama i nā ʻano ʻano like ʻole o ka maʻi lepera, e like me ka hoʻonui ʻia o nā lymph nodes, erythema nodosum, fever, arthralgia a me neuralgia me ka maikaʻi maikaʻi. .
Ua ʻokoʻa loa nā hopena immunomodulatory o ka thalidomide e like me nā kūlana hoʻokolohua, me nā hopena kū'ē i kekahi manawa.ʻO nā hopena ma nā lymphocytes ka emi ʻana o nā pūnaewele CD4+ a me ka hoʻoulu ʻana o nā pūnaewele CD8+, e hopena i ka emi ʻana o ka lakene CD48.
Eia kekahi, ʻike ʻia ka thalidomide i ka hoʻololi ʻana mai kahi Th1 a i kahi pane Th2.
Ua hana ʻo Cyclosporine a me thalidomide ma nā ʻano ʻelua o T lymphocytes, Th1 a me Th2, a ua ʻike ʻia ʻo Thd e hoʻoulu a hoʻonui i ka synthesis o IL-4 a me IL-5, e kāohi i ka synthesis o interferon gamma (IFN-γ) e phytohemagglutinin-hoʻoulu kanaka. nā monocytes koko peripheral, a hoʻemi i nā kiʻekiʻe o TNF-α, IL-6, a me IL-10 mRNA, me ka hopena ʻole o ka pae IL-12 a me IFN-γ mRNA ʻaʻohe hopena.
HL-Glu-OH | HD-Glu-OH | DL-Glu-OH | Boc-L-Glu-OH |
Boc-D-Glu-OH | Boc-Glu(trt)-OH | Fmoc-L-Glu-OH | Fmoc-D-Glu-OH |
Cbz-L-Glu-OH | Cbz-D-Glu-OH | Cbz-L-Glu-Otbu | Cbz-L-Glu(Oet)-OH |
1. No ka MOQ: Hiki iā mākou ke hoʻololi e like me kāu koi.
2. E pili ana i ka hāpana: Pono ka hāpana i ka uku hōʻailona, hiki ke lawe i ka ukana e hōʻiliʻili aiʻole hiki iāʻoe ke uku iā mākou ma mua.
3. Mold workshop, hiki ke hoʻopilikino ʻia e like me ka helu o nā hiʻohiʻona.
4. Hāʻawi mākou i ka lawelawe maikaʻi loa.Ke hana nei kekahi hui kūʻai akamai iā ʻoe.
5. E pili ana i ka hoʻololi: E ʻoluʻolu e leka uila a kamaʻilio mai iaʻu ma kou ʻoluʻolu.