428868-52-4 Fmoc-N-Me-L-Tyr(bzl)-OH

ʻO Fmoc-N-Me-L-Tyr(Bzl) -OH, i ʻike ʻia ʻo N-α-(9-fluorenylmethoxycarbonyl) -N-α-methyl-L-tyrosine benzyl ester, he mea hoʻohana ʻia i ka waika amino pale i hoʻohana mau ʻia i ka paʻa. - ka hana peptide synthesis.Hoʻohui kēia hui i ka pūʻulu pale Fmoc no ka terminal amino me kahi ester benzyl (Bzl) e pale ana i ka hui phenolic hydroxyl o L-tyrosine.

ʻO ka hui Fmoc he paʻa loa a hiki ke hoʻoheheʻe ʻia i nā mea hoʻoheheʻe organik, kahi e kūpono ai no ka synthesis peptide.Hiki iā ia ke wehe maʻalahi ma lalo o nā kūlana alkaline, e ʻae ai i ka hui pū ʻana o nā peptides ma nā kākoʻo paʻa.ʻO ka benzyl ester, ma ka ʻaoʻao ʻē aʻe, pale i ka pūʻulu phenolic hydroxyl o L-tyrosine, e pale ana i nā hopena makemake ʻole i ka wā o ke kaʻina hana synthesis.

ʻO ka noi mua o Fmoc-N-Me-L-Tyr (Bzl) -OH i ka hoʻomākaukau ʻana i nā peptides i loaʻa iā L-tyrosine.Ma ka hoʻokomo ʻana i kēia derivative amino acid i loko o ke kaʻina peptide, hiki i nā mea noiʻi ke hoʻohui i ka L-tyrosine me nā pūʻulu amino a me phenolic hydroxyl i pale ʻia.Hāʻawi kēia i ka mana pololei ma luna o ka hoʻolālā peptide a hoʻomaʻamaʻa i ka hoʻokomo ʻana i nā waikawa amino ʻē aʻe a me nā hoʻololi i nā kūlana kikoʻī i loko o ke kaulahao peptide.

ʻO L-Tyrosine kahi waikawa amino koʻikoʻi i ka meaʻai kanaka a loaʻa iā ia nā hana olaola like ʻole, me ka lawelawe ʻana ma ke ʻano he precursor no nā neurotransmitters a me ka hana melanin.Hiki ke hoʻohana ʻia nā peptide i loaʻa iā L-tyrosine e aʻo i kēia mau hana a i ʻole e hoʻomohala i nā lāʻau lapaʻau hou a i ʻole nā ​​​​mea lapaʻau.