NUI
No nā nīnau e pili ana i kā mākou huahana a i ʻole ka papa inoa kumukūʻai, e ʻoluʻolu e waiho i kāu leka uila iā mākou a e hoʻopili mākou i loko o 24 mau hola.
NINAU ANOKūlana halihali
Hiki i ka wela maʻamau
Manaʻo i ke ʻano hoʻouna
Ma ka lewa Ma ka aina Ma ke kai
Kūlana mālama:
E mālama i kahi pōʻeleʻele, Inert ea, lumi wela
Ola ola
Ma kahi o 2 makahiki
Ka nui o ke kauoha liʻiliʻi:
1kg (kūkākūkā)
palapala hōʻoia:COA, wahi hehee, Hoʻololi kikoʻī [α]D20
E hoʻouna mākou i nā ʻikepili āu e makemake ai.Hiki iā ʻoe ke ʻike i ka ʻikepili ma mua ma ke ʻano he kuhikuhi.
No nā huahana maʻamau, hoʻouna mākou i ka ʻikepili hou ma hope o ka puka ʻana mai.
(2S)-2-(tert-Butoxycarbonylamino)-3-methoxy-propanoicacid;
(S)-N-BOC-2-AMINO-3-METHOXY-PROPIONICACID;
N-ALPHA-T-BUTOXYCARBONYL-O-METHYL-L-SERINE;
N-ALPHA-T-BUTOXYCARBONYL-O-METHYL-LSERINEDICYCLOHEXYLAMMONIUMSALT;
N-ALPHA-T-BOC-O-METHYL-L-SERINE;
BOC-(S)-2-AMINO-3-METHOXYLPROPANOICACID;
BOC-(S)-2-AMINO-3-METHOXYPROPIONICACID
Hoʻohana pinepine ʻia lākou no ka hoʻopili ʻana i ka pauka.Pili ia i nā koi o nā mea kūʻai aku.No laila, e haʻi mai iā mākou i kāu koi ma mua o ka hoʻopaʻa ʻana inā loaʻa iā ʻoe nā noi kūikawā.
He paʻakikī ka paʻi waho.A he mea paʻakikī ke ʻoki a hōʻino.Hiki iā ia ke pale pono i kāu mau huahana.
Ka noiʻi biochemical:
Hana ʻo Boc-Ser(Me)-OH ma ke ʻano he reagent biochemical waiwai i ka synthesis protein, nā hopena enzymatic, a me nā haʻawina pili molecular.
Hiki iā ia ke hoʻohālikelike i ka hana o ka serine maoli, e hana ana i nā kaulahao peptide me nā waikawa amino ʻē aʻe a i ʻole nā ʻāpana peptide e hāʻawi i nā ʻike i ke ʻano o ka protein a me ka hana.
ʻIke lāʻau lapaʻau:
He kuleana koʻikoʻi ʻo Boc-Ser(Me)-OH i ka ʻike ʻana i ka lāʻau ma muli o kāna hana olaola.
Ma o ka hoʻololi ʻana a me ka hoʻoponopono ʻana, hiki iā ia ke lawelawe ma ke ʻano he moho lāʻau a i ʻole ka lāʻau precursor no ka hoʻomohala ʻana i nā therapeutics novel.
Hoʻohui ʻia, hiki ke hoʻohana ʻia i ka synthesis o nā lāʻau lapaʻau peptide me nā hana pharmacological a i ʻole ma ke ʻano he waena o ka synthesis lāʻau.
ʻO ka hoʻohuihui kino:
I loko o ka hoʻohuihui organik, lawelawe ʻo Boc-Ser(Me)-OH ma ke ʻano he synthetic intermediate no ke kūkulu ʻana i nā molekala organik paʻakikī.
ʻO nā hui pale Boc a me O-methyl i loko o kona hale e ʻae i ka pale ʻana i nā pūʻulu hana kikoʻī, e pale ana i nā hopena ʻaoʻao makemake ʻole i ka wā o ka hana synthetic.
Ma hope o ka pau ʻana o ka synthesis, hiki ke hoʻoneʻe ʻia kēia mau pūʻulu pale no ka loaʻa ʻana o ka mole i makemake ʻia.
ʻO ka peptide Synthesis:
Hoʻohana mau ʻia ʻo Boc-Ser(Me)-OH ma ke ʻano he waikawa amino hoʻomaka i ka synthesis peptide solid-phase.
Ma ka hoʻohui ʻana i nā koena amino acid ʻē aʻe, hiki ke hoʻohui ʻia nā kaulahao peptide me nā ʻano kikoʻī a me nā hale.
Hiki ke hoʻohana ʻia kēia mau kaulahao peptide i ka hoʻopaʻa ʻana i ka pilina o ka hoʻokumu ʻana o ka protein, ka hoʻomohala ʻana i nā lāʻau lapaʻau peptide hou, a i ʻole nā mea hoʻoponopono diagnostic.
L-Ser | H-DL-Ser-OH | D-Ser-OH |
L-Ser-Ol | L-Ser-Ol | L-Ser(Me)-OH |
HL-Ser(Me)-OH.HCl | DL-Ser(Me)-OH | D-Ser(me) |
HL-Ser(tBu)-OH | D-Ser(tBu)-OH | D-Ser(bzl) |
D-Ser(bzl).HCl | HL-Ser(Bzl)-OH.HCl | HL-Ser(Bzl)-OH |
HL-Ser(Bzl)-OL.HCl | HL-Ser-OMe.HCl | L-Ser-Oet.Hcl |
HL-Ser-OBzl.HCl | HL-Ser-OBzl | DL-Ser-Obzl.Hcl |
D-Ser-Obzl.Hcl | Boc-L-Ser(Bzl)-OH | Boc-DL-Ser(Bzl)-OH |
Boc-Ser(Bzl)-ol | Boc-D-Ser(Bzl)-OL | Boc-L-Ser-OMe |
Boc-L-Ser-Obzl | Boc-L-Ser(cl)-OMe | Fmoc-L-Ser(bzl)-OH |
Fmoc-D-Ser(bzl)-OH | Fmoc-N-Me-Ser(bzl) | ZL-Ser(Bzl)-OH |
Cbz-D-Ser(Bzl)-OH | Cbz-L-Ser-Ome | Cbz-DL-Ser-ome |
Cbz-D-Ser-Ome | Cbz-L-Ser-Obzl |
1. E pili ana i ka hoʻololi: E ʻoluʻolu e leka uila iaʻu a kamaʻilio pū me aʻu i kou ʻoluʻolu.
2. Kiʻekiʻe kiʻekiʻe: Ke hoʻohana nei i nā mea kiʻekiʻe kiʻekiʻe a me ka hoʻokumu ʻana i kahi ʻōnaehana mana koʻikoʻi, hāʻawi i nā poʻe kikoʻī e mālama i kēlā me kēia kaʻina hana, mai ke kūʻai ʻana i nā mea waiwai a hiki i ka ʻeke.
3. Mold workshop, customized model can be made by the quantity.
4. Hāʻawi mākou i ka lawelawe maikaʻi loa e like me mākou.Ke hana nei ka hui kūʻai ʻike no ʻoe.