NUI
No nā nīnau e pili ana i kā mākou huahana a i ʻole ka papa inoa kumukūʻai, e ʻoluʻolu e waiho i kāu leka uila iā mākou a e hoʻopili mākou i loko o 24 mau hola.
NINAU ANOKūlana halihali
Hiki i ka wela maʻamau
Manaʻo i ke ʻano hoʻouna
Ma ka lewa Ma ka aina Ma ke kai
Kūlana mālama:
E mālama i kahi pōʻeleʻele, Inert ea, lumi wela
Ola ola
Ma kahi o 2 makahiki
Ka nui o ke kauoha liʻiliʻi:
1kg (kūkākūkā)
palapala hōʻoia:COA, wahi hehee, Hoʻololi kikoʻī [α]D20
E hoʻouna mākou i nā ʻikepili āu e makemake ai.Hiki iā ʻoe ke ʻike i ka ʻikepili ma mua ma ke ʻano he kuhikuhi.
No nā huahana maʻamau, hoʻouna mākou i ka ʻikepili hou ma hope o ka puka ʻana mai.
N-ME-TYR(ME)-OH;
N-ME-TYROSINE(ME)-OH;
N-ME-P-METHOXY-PHE-OH
N-ME-4-METHOXY-PHE-OH;
N-ALPHA-METHYL-O-METHYL-L-TYROSINE;
N-ALPHA-METHYL-4-METHOXY-L-PHENYLALANINE
Hoʻohana pinepine ʻia lākou no ka hoʻopili ʻana i ka pauka.Pili ia i nā koi o nā mea kūʻai aku.No laila, e haʻi mai iā mākou i kāu koi ma mua o ka hoʻopaʻa ʻana inā loaʻa iā ʻoe nā noi kūikawā.
1kg a 25kg He paʻakikī ka paʻi waho.A he mea paʻakikī ke ʻoki a hōʻino.Hiki iā ia ke pale pono i kāu mau huahana.
Noiʻi Biochemical: N-Me-Tyr(Me)-OH he mea hana noiʻi koʻikoʻi no ke aʻo ʻana i ka hana a me ke kuleana o ka methylation protein i nā ʻōnaehana olaola.ʻO ka methylation kahi hoʻololi protein maʻamau e hiki ke hoʻopilikia i ka hana protein, kūpaʻa, a me nā pilina.
Hoʻolālā a me ka hoʻomohala ʻana i ka lāʻau lapaʻau: ʻO ka hana olaola o N-Me-Tyr(Me)-OH e lilo ia i wahi hoʻomaka no ka hoʻolālā lāʻau.Hiki i nā mea noiʻi ke ʻimi i nā moho lāʻau lapaʻau hou ma ka hoʻokomo ʻana i loko o nā molekele lāʻau lapaʻau, me ka manaʻo e mālama i nā maʻi like ʻole e like me ke kanesa, nā maʻi neurological, a me nā mea hou aku.
Nā Nānā Lapaʻau: Hiki ke hoʻohana ʻia ʻo N-Me-Tyr(Me)-OH no ka hoʻomākaukau ʻana i nā ʻōkuhi fluorescent a i ʻole nā lepili no nā diagnostics olakino a me ka lāʻau lapaʻau.Ma ka hoʻohui ʻana iā ia me nā biomolecules a i ʻole nā pūnaewele, hiki ke loaʻa ka ʻike mua a me ka hōʻoia ʻana i nā maʻi kūikawā.
ʻO ka Peptide a me ka Protein Synthesis: N-Me-Tyr (Me) -OH e lawelawe ma ke ʻano he hale kūkulu no ka synthesis o nā peptides a me nā protein.Hiki ke hui pū ʻia me nā waikawa amino ʻē aʻe e hana i nā kaulahao peptide a i ʻole nā protein me nā kaʻina a me nā hale kikoʻī.
FMOC-N-Me-D-Tyr(me)-OH | Boc-N-Me-L-Tyr(tbu)-OH | Fmoc-N-Me-L-Tyr(tBu)-OH | Cbz-N-Me-Tyr(tbu)-OH |
Fmoc-N-Me-D-Tyr(tBu)-OH | Boc-N-Me-L-Tyr(bzl)-OH | Fmoc-N-Me-L-Tyr(bzl)-OH | Boc-N-Me-D-Tyr(bzl)-OH |
1. No ka MOQ: Hiki iā mākou ke hoʻololi e like me kāu koi.
2. E pili ana i ka hāpana: Pono ka hāpana i ka uku hōʻailona, hiki ke lawe i ka ukana e hōʻiliʻili aiʻole hiki iāʻoe ke uku iā mākou ma mua.
3. Mold workshop, hiki ke hoʻopilikino ʻia e like me ka helu o nā hiʻohiʻona.
4. Hāʻawi mākou i ka lawelawe maikaʻi loa.Ke hana nei kekahi hui kūʻai akamai iā ʻoe.
5. E pili ana i ka hoʻololi: E ʻoluʻolu e leka uila a kamaʻilio mai iaʻu ma kou ʻoluʻolu.