53267-93-9 Tert-butoxycarbonyl-L-Tyrosine(methyl)-OH

ʻO Card bei oxytocin (Carbetocin) kahi ʻano synthesis o ka lōʻihi o ka hana me nā hiʻohiʻona o ka agonist oxytocin 8 peptide maʻiʻo, kona mau lāʻau lapaʻau a me ka lāʻau lapaʻau e like me ka oxytocin hua maoli.E like me ka oxytocin, hoʻopaʻa ʻo cabetin i nā mea hoʻokipa oxytocin i loko o ka ʻiʻo maʻemaʻe o ka ʻōpū, e hoʻoulu ai i ka rhythmic contractions o ka ʻōpū, e hoʻonui ana i kona alapine a me ka hoʻonui ʻana i ka ʻāʻī o ka ʻōpū ma luna o nā ʻoki kumu.He haʻahaʻa nā pae o ka oxytocin receptors i loko o ka ʻōpū i ka wā hāpai ʻole a hoʻonui i ka wā hāpai, piʻi i ka wā hānau.No laila, ʻaʻohe hopena o ka cabetin i ka ʻōpū ʻaʻole i hāpai ʻia, akā ua loaʻa nā ʻokiʻoki ʻana o ka ʻōpū i ka ʻōpū hāpai a me ka ʻōpū ma hope o ka hānau ʻana.Ma ka intravenously a i ʻole i loko o ka ʻōpū, ʻaelike wikiwiki ka ʻōpū, a hiki i ka ikaika paʻa i loko o 2 mau minuke.Hoʻokahi ka nui o ka capetin i lawelawe ʻia i loko o ka ʻōpū ma kahi o hoʻokahi hola, ʻo ia ka lawa e pale ai i ke koko postpartum ma hope koke o ka hānau ʻana.ʻOi aku ka lōʻihi o ke alapine a me ka nui o nā ʻokiʻoki ma hope o ka lawelawe ʻana o ka carpetine ma hope o ka oxytocin.Ua hōʻike ʻia nā haʻawina i ka hāʻawi ʻia ʻana o ka 100μg intravenously ma hope koke o ka pauku caesarean ma lalo o ka epidural a lumbar anesthesia, ʻoi aku ka maikaʻi o ka carbetin ma mua o ka placebo i ka pale ʻana i ka hypotonia uterine a me ka hōʻemi ʻana i ke koko postpartum.ʻO ka carpetine i hāʻawi ʻia i ka wā ma hope o ka hānau ʻana he hiki ke hoʻoikaika i ka hoʻōla ʻana o ka ʻōpū.
Hoʻopaʻa ʻo Cabetin i nā mea loaʻa oxytocin i loko o ka ʻiʻo maʻemaʻe o ka ʻōpū i mea e hoʻopaʻa ʻia ai ka ʻōpū me ka puʻupuʻu, e hoʻonui ana i ka pinepine o ka ʻoki ʻana a me ka hoʻonui ʻana i ka haʻalulu o ka ʻōpū.Hiki ke hāʻawi koke ʻia i hoʻokahi maʻa o ka carbetin ma hope o ka hānau ʻana o ka pēpē e pale ai i ke koko postpartum.Ua ʻike ʻia ʻo ka hoʻokomo ʻana o ka oxytocin i hui pū ʻia me ka cabetin hiki ke pale i ke kahe koko postpartum.Ma hope o ka pauku cesarean, hiki i ka hoʻohana ʻana i ka cabetin i hui pū ʻia me ka oxytocin ke hoʻoikaika i ka ʻōpū o ka ʻōpū, e hoʻemi i ka nui o ke kahe koko ma hope o ka pauku cesarean, ʻoi aku ka maikaʻi o ka hopena ma mua o ka hemabate.No nā wahine me ka ʻōpū cicatritic, placenta previa a me nā mea koʻikoʻi koʻikoʻi no ka hemorrhage postpartum, hiki i ka carbetin ke pale pono i ka hiki ʻana o ka hemorrhage postpartum.Hoʻohana ʻia ia no ka epidural a i ʻole lumbar anesthesia ma hope o ka pauku cesarean e pale i ka nāwaliwali o ka ʻōpū a me ka hemorrhage postpartum.