NUI
No nā nīnau e pili ana i kā mākou huahana a i ʻole ka papa inoa kumukūʻai, e ʻoluʻolu e waiho i kāu leka uila iā mākou a e hoʻopili mākou i loko o 24 mau hola.
NINAU ANOKūlana halihali
Hiki i ka wela maʻamau
Manaʻo i ke ʻano hoʻouna
Ma ka lewa Ma ka aina Ma ke kai
Kūlana mālama:
E mālama i kahi pōʻeleʻele, Inert ea, lumi wela
Ola ola
Ma kahi o 2 makahiki
Ka nui o ke kauoha liʻiliʻi:
1kg (kūkākūkā)
palapala hōʻoia:COA, wahi hehee, Hoʻololi kikoʻī [α]D20
E hoʻouna mākou i nā ʻikepili āu e makemake ai.Hiki iā ʻoe ke ʻike i ka ʻikepili ma mua ma ke ʻano he kuhikuhi.
No nā huahana maʻamau, hoʻouna mākou i ka ʻikepili hou ma hope o ka puka ʻana mai.
Cbz-N-Me-D-Leu-OH;
(R) -2-(((Benzyloxy) carbonyl) (methyl) amino) -4-methylpentanoic acid;
Cbz-N-Methyl-D-leucine;
D-Leucine, N-methyl-N-[(phenylmethoxy)carbonyl]-
Hoʻohana pinepine ʻia lākou no ka hoʻopili ʻana i ka pauka.Pili ia i nā koi o nā mea kūʻai aku.No laila, e haʻi mai iā mākou i kāu koi ma mua o ka hoʻopaʻa ʻana inā loaʻa iā ʻoe nā noi kūikawā.
1kg a 25kg He paʻakikī ka paʻi waho.A he mea paʻakikī ke ʻoki a hōʻino.Hiki iā ia ke pale pono i kāu mau huahana.
Peptide Synthesis: Ma ke ʻano he derivative o nā waikawa amino, Cbz-N-Me-D-Leu-OH ke kuleana koʻikoʻi i ka synthesis peptide.Hiki ke hoʻohana ʻia no ke kūkulu ʻana i nā kaulahao peptide me nā kaʻina kikoʻī a me nā hana ma o ka pane ʻana me nā waikawa amino ʻē aʻe.Loaʻa kēia mau kaulahao peptide i nā noi i ka ʻike lāʻau lapaʻau, ka noiʻi biochemical, a me ka biotechnology.
Noiʻi Biochemical: Ma muli o kāna ʻano kemika kūʻokoʻa, hiki ke hoʻohana ʻia ʻo Cbz-N-Me-D-Leu-OH ma ke ʻano he mea hana a i ʻole ka ʻimi noiʻi i nā haʻawina biochemical.Hiki ke hoʻohana ʻia no ka noiʻi ʻana i ka pilina o ka protein-ligand, ke ʻano o ka protein a me ka hana, nā kinetics enzyme, a me nā ʻano hana pale.
Loaʻa i ka lāʻau lapaʻau: Loaʻa iā Cbz-N-Me-D-Leu-OH nā hana olaola hiki ke hoʻololi i ka hana protein a hoʻoponopono i nā kaʻina hana olaola.No laila, hiki iā ia ke lilo i moho no ka hoʻomohala ʻana i nā lāʻau lapaʻau hou.Eia nō naʻe, koi ʻia ka noiʻi hou aʻe e wehewehe i kāna mau hana olaola, nā waiwai pharmacokinetic, a me ka ʻike palekana i loko o vivo e loiloi i kona hiki ke hoʻōla.
N-Me-L-Leu | N-me-D-leu-obzl | Boc-N-Me-L-Leu-OH | Cbz-N-Me-L-Leu-OH |
Fmoc-LN-Me-Leu-OH | Boc-N-Me-D-Leu-OH | Fmoc-N-Me-D-Leu-OH |
1. No ka MOQ: Hiki iā mākou ke hoʻololi e like me kāu koi.
2. E pili ana i ka hāpana: Pono ka hāpana i ka uku hōʻailona, hiki ke lawe i ka ukana e hōʻiliʻili aiʻole hiki iāʻoe ke uku iā mākou ma mua.
3. Mold workshop, hiki ke hoʻopilikino ʻia e like me ka helu o nā hiʻohiʻona.
4. Hāʻawi mākou i ka lawelawe maikaʻi loa.Ke hana nei kekahi hui kūʻai akamai iā ʻoe.
5. E pili ana i ka hoʻololi: E ʻoluʻolu e leka uila a kamaʻilio mai iaʻu ma kou ʻoluʻolu.