66638-37-7 Boc-N-Me-L-Tyr(tbu)-OH

ʻO ka peptide Synthesis:
ʻO Boc-N-Me-L-Tyr(Tbu)-OH he ʻakika amino pale ʻia i hoʻohana mau ʻia i ka solid-phase peptide synthesis (SPPS) a me nā ʻano hana peptide synthesis ʻē aʻe.Me ka N-terminal a me ka ʻaoʻao-chain hydroxyl pūʻulu pale, mālama ia i ka paʻa i ka wā elongation kaulahao peptide, e pale ana i nā hopena ʻaoʻao makemake ʻole.
Ma hope o ka pau ʻana o ke kaulahao peptide, hiki ke hoʻoneʻe ʻia nā pūʻulu pale ma lalo o nā kūlana kūpono, e hōʻike ana i nā pūʻulu amino a me hydroxyl manuahi, a laila e hāʻawi i ka peptide a i ʻole ka protein i makemake ʻia.
ʻEnekinia Protein:
I ka ʻenekinia protein, hiki ke hoʻohana ʻia kēia waikawa amino i pale ʻia no ka hoʻololi ʻana i nā protein.Ma ka pane ʻana iā Boc-N-Me-L-Tyr(Tbu)-OH me nā wahi kikoʻī ma luna o kahi protein, hiki ke hoʻokomo ʻia kahi koena tyrosine methylated, e hoʻololi ana i nā waiwai a me ka hana o ka protein.
Hoʻolālā a me ka hoʻomohala ʻana i ka lāʻau lapaʻau:
Hiki i ka methylated tyrosine ke hōʻike i nā hana olaola kūikawā a i ʻole nā ​​waiwai pharmacokinetic i kekahi mau hoʻolālā lāʻau.Ma ka hoʻohana ʻana iā Boc-N-Me-L-Tyr(Tbu)-OH ma ke ʻano he hale kūkulu hale, hiki i nā mea noiʻi ke ʻimi i ka hopena therapeutic kūpono a me nā waiwai pharmacological o nā molekala lāʻau i loaʻa i ka tyrosine methylated.
Ka noiʻi biochemical a me ke olaola:
Ma ka noiʻi biochemical a me ka biological, hiki i kēia amino acid i mālama ʻia ma ke ʻano he mea paahana e aʻo ai i ka hana o ka methylated tyrosine i nā pilina protein, ka hoʻololi ʻana i ka hōʻailona, ​​​​ka hana enzyme, a me nā mea ʻē aʻe.
Bioconjugation a me ka Lepili:
ʻO nā pūʻulu methyl a me ka hydroxyl pale o Boc-N-Me-L-Tyr(Tbu)-OH he koho kūpono no ka bioconjugation a me ka hoʻopaʻa inoa ʻana.Ma ka wehe ʻana i nā pūʻulu pale a me ka pane ʻana me nā molekala ʻē aʻe a i ʻole nā ​​mea hana biologically, hiki ke hoʻomākaukau ʻia nā molekala i hōʻailona ʻia me nā hana olaola.