NUI
No nā nīnau e pili ana i kā mākou huahana a i ʻole ka papa inoa kumukūʻai, e ʻoluʻolu e waiho i kāu leka uila iā mākou a e hoʻopili mākou i loko o 24 mau hola.
NINAU ANOKūlana halihali
Hiki i ka wela maʻamau
Manaʻo i ke ʻano hoʻouna
Ma ka lewa Ma ka aina Ma ke kai
Kūlana mālama:
E mālama i kahi pōʻeleʻele, Inert ea, lumi wela
ola mālama
Ma kahi o 2 makahiki
Ka nui o ke kauoha liʻiliʻi:
1kg (kūkākūkā)
palapala hōʻoia:COA, wahi hehee, Hoʻololi kikoʻī [α]D20
E hoʻouna mākou i nā ʻikepili āu e makemake ai.Hiki iā ʻoe ke ʻike i ka ʻikepili ma mua ma ke ʻano he kuhikuhi.
No nā huahana maʻamau, hoʻouna mākou i ka ʻikepili hou ma hope o ka puka ʻana mai.
N-(Benzyloxycarbonyl)-N-methyl-D-alanine;
N-Methyl-N-Cbz-Ala;
Cbz-N-Me-D-Ala-OH;
BENZYLOXYCARBONYL-N-METHYL-D-ALANINE;
N-ALPHA-BENZYLOXYCARBONYL-N-ALPHA-METHYL-D-ALANINE;
N-ALPHA-CBZ-N-ALPHA-METHYL-D-ALANINE;
N-ALPHA-CARBOBENZOXY-N-METHYL-D-ALANINE;
ZD-MEALA-OH
Hoʻohana pinepine ʻia lākou no ka hoʻopili ʻana i ka pauka.Pili ia i nā koi o nā mea kūʻai aku.No laila, e haʻi mai iā mākou i kāu koi ma mua o ka hoʻopaʻa ʻana inā loaʻa iā ʻoe nā noi kūikawā.
1kg a 25kg He paʻakikī ka paʻi waho.A he mea paʻakikī ke ʻoki a hōʻino.Hiki iā ia ke pale pono i kāu mau huahana.
ʻO Cbz-N-Me-D-Ala-OH, ma ke ʻano he amino acid derivative, ʻike i nā noi ākea i ka kemika, biochemistry, a me ka ʻike lāʻau.
ʻO ka mea mua, ma ke kahua o ke kemika, hoʻohana pinepine ʻia ʻo Cbz-N-Me-D-Ala-OH ma ke ʻano he mea maka a i ʻole waena no ka synthesis organik.Hoʻopaʻa ka pūʻulu pale Cbz (carbobenzyloxy) i ka pūʻulu amino i ka wā o nā hopena, e hoʻomaʻamaʻa i nā hoʻololi kemika ma hope e like me ka peptide synthesis a i ʻole nā hoʻololi pūʻulu hana.Ma lalo o nā kūlana hopena kūikawā, hiki ke wehe maikaʻi ʻia ka hui pale Cbz e hōʻike i ka pūʻulu amino no ka hana hou aku.
ʻO ka lua, ma ka biochemistry, lawelawe ʻo Cbz-N-Me-D-Ala-OH ma ke ʻano he hale kūkulu hale no nā molekole bioactive.Hāʻawi kāna ʻano D-type amino acid i nā hana kūlohelohe kūʻokoʻa, hiki iā ia ke hana i kahi kuleana kūikawā i ka synthesis o nā protein a i ʻole nā kaulahao peptide.Hoʻohui ʻia, hiki ke hoʻohana ʻia ma ke ʻano he probe a i ʻole lepili i nā noiʻi biochemical e noiʻi i ka pilina ma waena o nā molekala olaola.
ʻO ka mea hope loa, i ka loaʻa ʻana o ka lāʻau lapaʻau, paʻa ʻo Cbz-N-Me-D-Ala-OH i ka waiwai therapeutic kūpono.ʻO kona ʻano kemika kūʻokoʻa a me kāna hana olaola hiki ke hoʻolilo iā ia i moho lāʻau lapaʻau maikaʻi a i ʻole ka hui alakaʻi.Ma o ka hoʻololi ʻana a me ka hoʻoponopono ʻana, hiki iā ia ke hōʻike i ka hiki ke therapeutic i ka mālama ʻana i kekahi mau maʻi a i ʻole nā kūlana.
L-ALa | DL-ALA | D-ALa | HN-Me-L-Ala-OH |
N-Me-L-Ala-OMe | N-Me-L-Ala-Ome.Hcl | Boc-N-Me-Ala-OH | Boc-N-Me-DL-Ala-OH |
Fmoc-LN-Me-Ala-OH | Fmoc-N-Me-D-Ala-OH | HN-Me-L-Ala-OH | Cbz-N-Me-L-Ala-OH |
1. No ka MOQ: Hiki iā mākou ke hoʻololi e like me kāu koi.
2. E pili ana i ka hāpana: Pono ka hāpana i ka uku hōʻailona, hiki ke lawe i ka ukana e hōʻiliʻili aiʻole hiki iāʻoe ke uku iā mākou ma mua.
3. Mold workshop, hiki ke hoʻopilikino ʻia e like me ka helu o nā hiʻohiʻona.
4. Hāʻawi mākou i ka lawelawe maikaʻi loa.Ke hana nei kekahi hui kūʻai akamai iā ʻoe.
5. E pili ana i ka hoʻololi: E ʻoluʻolu e leka uila a kamaʻilio mai iaʻu ma kou ʻoluʻolu.