NUI
No nā nīnau e pili ana i kā mākou huahana a i ʻole ka papa inoa kumukūʻai, e ʻoluʻolu e waiho i kāu leka uila iā mākou a e hoʻopili mākou i loko o 24 mau hola.
NINAU ANOKūlana halihali
Hiki i ka wela maʻamau
Manaʻo i ke ʻano hoʻouna
Ma ka lewa Ma ka aina Ma ke kai
Kūlana mālama:
E mālama i kahi pōʻeleʻele, Inert ea, lumi wela
ola mālama
Ma kahi o 2 makahiki
Ka nui o ke kauoha liʻiliʻi:
1kg (kūkākūkā)
palapala hōʻoia:COA, wahi hehee, Hoʻololi kikoʻī [α]D20
E hoʻouna mākou i nā ʻikepili āu e makemake ai.Hiki iā ʻoe ke ʻike i ka ʻikepili ma mua ma ke ʻano he kuhikuhi.
No nā huahana maʻamau, hoʻouna mākou i ka ʻikepili hou ma hope o ka puka ʻana mai.
(2S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}(methyl)amino)propanoicacid;
Fmoc-N-Me-DL-Alanine;
Fmoc-N-methyl-L-alanine≥99%(HPLC);
(9H-Fluoren-9-yl)MethOxy]CarbonylN-Me-Ala-OH;
N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methyl-L-alanine;
(S)-2-((((9H-Fluoren-9-yl)Methoxy)carbonyl)(Methyl)aMino)propanoicacid;
N-FMoc-N-Methyl-L-alanine,95%;
Fmoc-N-Me-L-Alanine
Hoʻohana pinepine ʻia lākou no ka hoʻopili ʻana i ka pauka.Pili ia i nā koi o nā mea kūʻai aku.No laila, e haʻi mai iā mākou i kāu koi ma mua o ka hoʻopaʻa ʻana inā loaʻa iā ʻoe nā noi kūikawā.
1kg a 25kg He paʻakikī ka paʻi waho.A he mea paʻakikī ke ʻoki a hōʻino.Hiki iā ia ke pale pono i kāu mau huahana.
ʻO ka Peptide Synthesis: Fmoc-LN-Me-Ala-OH e lawelawe ana ma ke ʻano he hale kūkulu hale i ka peptide synthesis solid-phase.ʻO ka pūʻulu Fmoc (9-fluorenylmethoxycarbonyl) he pūʻulu pale i hoʻohana nui ʻia e hiki ai ke hoʻopaʻa ʻia a me nā hopena hoʻopili kikoʻī i ka wā elongation kaulahao peptide.Hoʻokomo ka moiety LN-Me-Ala i kahi waikawa amino kikoʻī me nā waiwai kemika i hoʻololi ʻia e hiki ai ke alakaʻi i nā peptides me nā hana kūlohelohe kū hoʻokahi.
Nā Haʻawina Ola Ola: ʻO ka hiki ʻana mai o ka hui N-methyl i Fmoc-LN-Me-Ala-OH e hoʻololi i nā waiwai olaola o ke koena alanine, hiki ke hāʻawi i nā bioactivities hou i nā peptides i loko.No laila, hiki ke hoʻohana ʻia kēia pūhui no ka noiʻi ʻana i nā hana olaola, e like me ka launa pū ʻana o ka protein-protein, ka hoʻopaʻa ʻana i ka enzyme, a i ʻole ka hoʻopaʻa ʻana i ka mea hoʻopaʻa, in vitro a i ʻole i nā hiʻohiʻona kelepona.
Hoʻolālā a me ka hoʻomohala ʻana i ka lāʻau lapaʻau: Ua loaʻa i nā peptides ka hoihoi nui i ka hoʻolālā lāʻau ma muli o ko lākou kikoʻī kiʻekiʻe a me ka biocompatibility.ʻO ka hoʻokomo ʻana i nā waikawa amino i hoʻololi ʻia e like me Fmoc-LN-Me-Ala-OH hiki ke hoʻonui i ka paʻa, solubility, a i ʻole ka hana olaola o nā peptides, e hoʻohiki iā lākou i nā moho no nā noi therapeutic.Hiki i nā mea noiʻi ke hoʻohana i kēia pūhui no ka nānā ʻana i nā alakaʻi lāʻau lapaʻau a i ʻole e hoʻopaʻa pono i nā waiwai pharmacological o nā lāʻau lapaʻau peptide i loaʻa.
Nā Haʻawina Hoʻolālā a me Conformational: Hiki ke hoʻohana ʻia nā waiwai kemika kūʻokoʻa o Fmoc-LN-Me-Ala-OH i nā haʻawina biology structural.Ma ka hoʻokomo ʻana i kēia derivative amino acid i loko o nā peptides, hiki i nā mea noiʻi ke noiʻi i ka hopena o ka hoʻololi ʻana i ke kaʻina amino acid i nā makemake conformational, kūpaʻa, a me nā pilina o kēia mau peptides me nā biomolecules ʻē aʻe.
L-ALa | DL-ALA | D-ALa | HN-Me-L-Ala-OH |
N-Me-L-Ala-OMe | N-Me-L-Ala-Ome.Hcl | Boc-N-Me-Ala-OH | Boc-N-Me-DL-Ala-OH |
HN-Me-L-Ala-OH | Fmoc-N-Me-D-Ala-OH | Cbz-N-Me-D-Ala-OH | Cbz-N-Me-L-Ala-OH |
1. No ka MOQ: Hiki iā mākou ke hoʻololi e like me kāu koi.
2. E pili ana i ka hāpana: Pono ka hāpana i ka uku hōʻailona, hiki ke lawe i ka ukana e hōʻiliʻili aiʻole hiki iāʻoe ke uku iā mākou ma mua.
3. Mold workshop, hiki ke hoʻopilikino ʻia e like me ka helu o nā hiʻohiʻona.
4. Hāʻawi mākou i ka lawelawe maikaʻi loa.Ke hana nei kekahi hui kūʻai akamai iā ʻoe.
5. E pili ana i ka hoʻololi: E ʻoluʻolu e leka uila a kamaʻilio mai iaʻu ma kou ʻoluʻolu.