NUI
No nā nīnau e pili ana i kā mākou huahana a i ʻole ka papa inoa kumukūʻai, e ʻoluʻolu e waiho i kāu leka uila iā mākou a e hoʻopili mākou i loko o 24 mau hola.
NINAU ANOKūlana halihali
Hiki i ka wela maʻamau
Manaʻo i ke ʻano hoʻouna
Ma ka lewa Ma ka aina Ma ke kai
Kūlana mālama:
E mālama i kahi pōʻeleʻele, Inert ea, lumi wela
Ola ola
Ma kahi o 2 makahiki
Ka nui o ke kauoha liʻiliʻi:
1kg (kūkākūkā)
palapala hōʻoia:COA, wahi hehee, Hoʻololi kikoʻī [α]D20
E hoʻouna mākou i nā ʻikepili āu e makemake ai.Hiki iā ʻoe ke ʻike i ka ʻikepili ma mua ma ke ʻano he kuhikuhi.
No nā huahana maʻamau, hoʻouna mākou i ka ʻikepili hou ma hope o ka puka ʻana mai.
methyl 2-tert-butoxycarbonylamino-2-methylpropanoate;
methyl 2-aminobutoxycarbonyl-2-methylpropanoate;
N-tert-butoxycarbonyl-α-methylalanine methyl ester;
methyl 2-(tert-butoxycarbonylamino) -2-methylpropanoate;
N-(tert-butoxycarbonyl)-α-methylalanine methyl ester;
methyl N-(tert-butoxycarbonyl)-2-methyl-alaninate;
Hoʻohana pinepine ʻia lākou no ka hoʻopili ʻana i ka pauka.Pili ia i nā koi o nā mea kūʻai aku.E hōʻoia mākou i ka pūʻolo me ʻoe ma mua a ma hope o ka puka ʻana mai o nā huahana a hoʻouna iā ʻoe i nā kiʻi.
He paʻakikī ka paʻi waho.A he mea paʻakikī ke ʻoki a hōʻino.Hiki iā ia ke pale pono i kāu mau huahana.
ʻO ka Peptide Synthesis: lawelawe ʻo Boc-Aib-Ome ma ke ʻano he hale kūkulu hale i ka synthesis peptide solid-phase.Hiki ke hoʻohui ʻia i loko o nā kaulahao peptide e hoʻolauna i nā kaʻina amino acid kikoʻī.Hiki i ka hui pale Boc ke hoʻopaʻa ʻia i ka hoʻopili ʻana, e hōʻoia ana i ka hui pololei ʻana o nā peptides.Ke pau ka peptide synthesis, hiki ke wehe ʻia ka hui Boc e hōʻike i ka hana amino no nā hoʻololi hou a i ʻole conjugation.
Loaʻa i ka lāʻau lapaʻau: ʻike ʻo Boc-Aib-Ome i nā noi i ka hoʻolālā ʻana i nā lāʻau lapaʻau peptide hou.Ma ka hoʻokomo ʻana i kēia derivative amino acid i loko o nā kaʻina peptide, hiki i nā mea noiʻi ke ʻimi i nā mea lapaʻau kūpono me nā hana biological kūʻokoʻa.Hāʻawi ka hui pale Boc i ka paʻa i ka wā o ka hana synthetic, hiki ke hoʻomākaukau i nā conjugates peptide me nā waiwai pharmacokinetic i hoʻomaikaʻi ʻia.
Bioconjugation: Hiki ke hoʻohana ʻia ʻo Boc-Aib-Ome i nā hopena bioconjugation e hoʻopili i nā peptides a i ʻole nā protein i nā molekala olaola ʻē aʻe.Hiki i ka hana methyl ester ke hoʻopili covalent i nā molekole like ʻole, e like me nā antibodies, carbohydrates, a i ʻole nā peptides ʻē aʻe.Hāʻawi kēia i ka hana ʻana i nā ʻōnaehana hoʻopuka i manaʻo ʻia, biosensors, a i ʻole nā conjugates bioactive ʻē aʻe me ka hana i hoʻonui ʻia.
Nā Haʻawina Biochemical: Hiki ke hoʻohana ʻia ʻo Boc-Aib-Ome ma ke ʻano he mea hana i nā noiʻi biochemical e noiʻi ai i ka pilina protein-protein, enzyme kinetics, a i ʻole substrate specificity.Ma ka hoʻokomo ʻana i kēia derivative amino acid i loko o nā peptides i hoʻohana ʻia ma ke ʻano he probes a i ʻole inhibitors, hiki i nā mea noiʻi ke loaʻa nā ʻike i nā hana o nā kaʻina hana olaola.
Aib | Boc-Tyr(Akā).Aib | 2-Aib-Ome.Hcl |
2-Aib-Ome.Hcl | 2-Aib-Ome.Hcl | L-Aib-Oet.Hcl |
Boc-Aib-OH | Boc-Aib-OH | Boc-Aib-OH |
Boc-aib-Ome | Fmoc-Aib-OH | Fmoc-Aib-OH |
Fmoc-Aib-OH | Fmoc-Aib-OH | Fmoc-Aib-OH |
Fmoc-Aib-OH | Z-Aib-OH | Cbz-Aib-Otbu |
1. Hāʻawi mākou i ka hana maʻamau i nā huahana āu e pono ai.
2. Hiki ke hāʻawi ʻia ke kumukūʻai kiʻekiʻe & hoʻokūkū.
3.We hoʻohiki i kahi papa piha o ka lawelawe ukali no ʻoe.
4. Hiki ke hā'awi 'ia ka nīnau nīnau mea kū'ai a me nā palapala 'ike loea inā noi ma hope o ka hālāwai 'ana i kekahi huina.
5. Nui ma hope o ke kūʻai aku ʻana a i ʻole ka hōʻoia ʻana: E hoʻoponopono koke ʻia kāu nīnau i ka hiki.
6. E hoʻokuʻu aku i nā huahana hoʻokūkū a hoʻokuʻu aku iā lākou i waho i nā mea nui i kēlā me kēia makahiki.
7.Free hāpana hāʻawi ʻia e nānā i ka maikaʻi ma mua o kekahi uku.