NUI
No nā nīnau e pili ana i kā mākou huahana a i ʻole ka papa inoa kumukūʻai, e ʻoluʻolu e waiho i kāu leka uila iā mākou a e hoʻopili mākou i loko o 24 mau hola.
NINAU ANOKūlana halihali
Hiki i ka wela maʻamau
Manaʻo i ke ʻano hoʻouna
Ma ka lewa Ma ka aina Ma ke kai
Kūlana mālama:
E mālama i kahi pōʻeleʻele, Inert ea, lumi wela
ola mālama
Ma kahi o 2 makahiki
Ka nui o ke kauoha liʻiliʻi:
1kg (kūkākūkā)
palapala hōʻoia:COA, wahi hehee, Hoʻololi kikoʻī [α]D20
E hoʻouna mākou i nā ʻikepili āu e makemake ai.Hiki iā ʻoe ke ʻike i ka ʻikepili ma mua ma ke ʻano he kuhikuhi.
No nā huahana maʻamau, hoʻouna mākou i ka ʻikepili hou ma hope o ka puka ʻana mai.
D-Leucine, N-methyl-, phenylmethyl ester;
(R)-Benzyl 4-methyl-2-(methylamino)pentanoate;
HN-Me-D-Leu-OBzl;
N-me-D-leu-obzl
Hoʻohana pinepine ʻia lākou no ka hoʻopili ʻana i ka pauka.Pili ia i nā koi o nā mea kūʻai aku.No laila, e haʻi mai iā mākou i kāu koi ma mua o ka hoʻopaʻa ʻana inā loaʻa iā ʻoe nā noi kūikawā.
1kg a 25kg He paʻakikī ka paʻi waho.A he mea paʻakikī ke ʻoki a hōʻino.Hiki iā ia ke pale pono i kāu mau huahana.
ʻIke ʻana i ka lāʻau lapaʻau a me ka Synthesis: N-Me-D-Leu-Obzl lawelawe ma ke ʻano he hale kūkulu waiwai i ka synthesis o nā molekala lāʻau paʻakikī.Ma o ka hoʻololi ʻana me nā mea hoʻokalakupua ʻē aʻe, hiki ke hoʻohana ʻia e hana i nā lāʻau lapaʻau me nā hale kikoʻī a me nā hana koʻikoʻi i makemake ʻia, hiki ke kuhikuhi ʻia i nā maʻi like ʻole a i ʻole nā kaʻina hana olaola.
ʻO ka Peptide Synthesis a me ka Hoʻololi: ʻO nā hoʻololi methylated a me benzylated o N-Me-D-Leu-Obzl hiki ke hoʻololi i nā waiwai physicochemical a me nā hana ola o nā peptides.Hāʻawi ia i ka synthesis o nā peptides me ka hoʻomaikaʻi ʻana i ke kūpaʻa, hoʻololi ʻia ka pilina me nā molekala ʻē aʻe, a i ʻole i hoʻololi ʻia i ka huli ʻana intracellular, e lilo ia i mea pono i ka ʻenehana peptide.
Nā Mākaʻikaʻi Biological and Imaging Agents: Ma ka hoʻohui ʻana i ka N-Me-D-Leu-Obzl me nā mea hoʻonaninani fluorescent, radiolabels, a i ʻole nā molekole mea hoʻolaha ʻē aʻe, hiki ke hoʻololi ʻia i loko o nā probes biological a i ʻole nā mea hana kiʻi.Hiki i kēia mau ʻimi noiʻi ke ʻike a me ka helu ʻana o nā kaʻina olaola kikoʻī i loko o nā cell a i ʻole nā kikoʻī, e hāʻawi ana i nā ʻike i nā hana kelepona a me nā mīkini maʻi.
Mea Hana Noiʻi ma Biochemistry: Hiki ke hoʻohana ʻia ʻo N-Me-D-Leu-Obzl ma ke ʻano he mea hana noiʻi i ka biochemistry, e ʻae ana i nā ʻepekema e noiʻi i nā pilina protein-protein, kinetics enzyme, a i ʻole nā kaʻina biochemical ʻē aʻe.Hiki i kāna hana kemika kū hoʻokahi ke hāʻawi i nā ʻike waiwai i nā kikoʻī mechanistic o kēia mau kaʻina hana.
Fmoc-N-Me-D-Leu-OH | N-Me-L-Leu | Boc-N-Me-L-Leu-OH | Cbz-N-Me-L-Leu-OH |
Fmoc-LN-Me-Leu-OH | Boc-N-Me-D-Leu-OH | Cbz-N-Me-D-Leu-OH |
1. No ka MOQ: Hiki iā mākou ke hoʻololi e like me kāu koi.
2. E pili ana i ka hāpana: Pono ka hāpana i ka uku hōʻailona, hiki ke lawe i ka ukana e hōʻiliʻili aiʻole hiki iāʻoe ke uku iā mākou ma mua.
3. Mold workshop, hiki ke hoʻopilikino ʻia e like me ka helu o nā hiʻohiʻona.
4. Hāʻawi mākou i ka lawelawe maikaʻi loa.Ke hana nei kekahi hui kūʻai akamai iā ʻoe.
5. E pili ana i ka hoʻololi: E ʻoluʻolu e leka uila a kamaʻilio mai iaʻu ma kou ʻoluʻolu.