NUI
No nā nīnau e pili ana i kā mākou huahana a i ʻole ka papa inoa kumukūʻai, e ʻoluʻolu e waiho i kāu leka uila iā mākou a e hoʻopili mākou i loko o 24 mau hola.
NINAU ANOKūlana halihali
Hiki i ka wela maʻamau
Manaʻo i ke ʻano hoʻouna
Ma ka lewa Ma ka aina Ma ke kai
Kūlana mālama:
E mālama i kahi pōʻeleʻele, Inert ea, lumi wela
Ola ola
Ma kahi o 2 makahiki
Ka nui o ke kauoha liʻiliʻi:
1kg (kūkākūkā)
palapala hōʻoia:COA, wahi hehee, Hoʻololi kikoʻī [α]D20
E hoʻouna mākou i nā ʻikepili āu e makemake ai.Hiki iā ʻoe ke ʻike i ka ʻikepili ma mua ma ke ʻano he kuhikuhi.
No nā huahana maʻamau, hoʻouna mākou i ka ʻikepili hou ma hope o ka puka ʻana mai.
N-(TERT-BUTOXYCARBONYL)-D-SERINEMETHYLESTER;
BOC-D-SERINEMETHYLESTER;
BOC-D-SER-OME;
D-Serine,N-[(1,1-dimethylethoxy)carbonyl]-,methylChemicalbookester(9CI);
N-(TERT-BBUTOXYCARBONYL)-L-SERINEMETHYLESTER;
BOC-D-SERINEMETHYLESTEROIL;
N-BOC-D-serinemethylester;
N-BOC-D-ser-methylester
Hoʻohana pinepine ʻia lākou no ka hoʻopili ʻana i ka pauka.Pili ia i nā koi o nā mea kūʻai aku.No laila, e haʻi mai iā mākou i kāu koi ma mua o ka hoʻopaʻa ʻana inā loaʻa iā ʻoe nā noi kūikawā.
He paʻakikī ka paʻi waho.A he mea paʻakikī ke ʻoki a hōʻino.Hiki iā ia ke pale pono i kāu mau huahana.
Peptide Synthesis: He hana koʻikoʻi ʻo Boc-D-Ser-OMe i ka peptide synthesis.Hiki ke hoʻohui ʻia me nā waikawa amino ʻē aʻe e hana i nā kaulahao peptide me nā ʻano kikoʻī a me nā hale.ʻO ka hui pale Boc e hōʻoia i nā hopena koho a hoʻomaluʻia, e maʻalahi i ka hui pololei o nā peptides.Hoʻohana pinepine ʻia kēia derivative amino acid i ka solid-phase peptide synthesis e kūkulu i nā peptides me nā hana biological makemake.
ʻIke Laʻau Laʻau: Loaʻa ʻo Boc-D-Ser-OMe i nā noi ma ka noiʻi ʻike lāʻau.ʻO kona hoʻokomo ʻana i nā molekala lāʻau hiki ke alakaʻi i ka hoʻomohala ʻana i nā therapeutics hou me nā pono therapeutic kūpono.Hiki i ka D-configuration o serine ke hāʻawi i nā waiwai kūʻokoʻa i ka lāʻau lapaʻau, e like me ka hoʻomaikaʻi ʻana i ka paʻa, ka koho, a i ʻole ka pharmacokinetic profile.Hiki ke hoʻohana ʻia kēia mau lāʻau lapaʻau no ka mālama ʻana i nā maʻi like ʻole, e like me ke kanesa, nā maʻi neurological, a me nā maʻi lele.
Nā Haʻawina Biochemical: ʻO Boc-D-Ser-OMe kahi mea hana waiwai i nā noiʻi biochemical, ʻoi loa i ka ʻimi ʻana i nā hana a me nā pilina o nā protein i loko o ka serine.Ma ka hoʻokomo ʻana i kēia derivative amino acid i loko o nā peptides i hoʻohana ʻia ma ke ʻano he probes a i ʻole inhibitors, hiki i nā mea noiʻi ke loaʻa nā ʻike i nā hana o nā kaʻina hana olaola pili i ka serine.
Bioconjugation: Hiki ke hoʻohana ʻia ʻo Boc-D-Ser-OMe i nā hopena bioconjugation no ka hoʻopili ʻana i nā peptides a i ʻole nā protein i nā molekala olaola ʻē aʻe.Hiki i ka hana methyl ester ke hoʻopili covalent i nā antibodies, carbohydrates, a i ʻole nā peptides ʻē aʻe, e hana ana i nā ʻōnaehana hoʻopuka i manaʻo ʻia, biosensors, a i ʻole nā conjugates bioactive ʻē aʻe me ka hana i hoʻonui ʻia.
D-Ser(me)-Ome.Hcl | HL-Ser(tBu)-OMe |
H-Ser(tBu)-OMe.HCl | HD-Ser(tBu)-OMe |
HD-Ser(tBu)-OMe.HCl | HL-Ser(Bzl)-OMe·HCl |
Boc-L-Ser-OMe | Boc-DL-Ser-Ome |
Boc-D-Ser-OMe | Boc-L-Ser(cl)-OMe |
Fmoc-Ser-Ome | Fmoc-D-Ser-Ome |
Cbz-L-Ser-Ome | Cbz-DL-Ser-ome |
Cbz-D-Ser-Ome |
1. E pili ana i ke kumukūʻai: Hiki ke kūkākūkā ke kumukūʻai.Hiki ke hoʻololi e like me kāu nui.
2. Hāʻawi mākou i ka lawelawe maikaʻi loa.Ke hana nei kekahi hui kūʻai akamai iā ʻoe.
3. E pili ana i ka laʻana: Pono ka hāpana i ka uku hōʻailona, hiki ke lilo i ka ukana e hōʻiliʻili aiʻole hiki iāʻoe ke uku iā mākou ma mua.