130622-05-8 Tert-butoxycarbonyl-D-glutamic acid(methyl ester)-methyl ester

Loaʻa nā Fluoroquinolones i ka spectrum antibacterial ākea, ka hana antibacterial ikaika, nā hopena haʻahaʻa haʻahaʻa, ka permeability maikaʻi o ka ʻiʻo, ka bioavailability waha kiʻekiʻe, ka wā hoʻokele lōʻihi a me ka hoʻokele kūpono.Hoʻohana maʻamau ʻia lākou i ka mālama ʻana i nā maʻi ʻeha e like me ka maʻi ʻeha a me ka maʻi urinary tract.Hōʻike ʻia ke ʻano o nā lāʻau antibacterial fluoroquinolone e ka hele ʻana o ka fluorine ma ke kūlana ʻeono o ka nucleus makua quinolone.
Eia nō naʻe, i nā makahiki he 10 i hala iho nei, ma muli o ke kaomi koho i hana ʻia e ka hoʻohana ākea o kēia ʻano o nā lāʻau lapaʻau, piʻi aʻe nā ʻano lāʻau kūʻē i ka lāʻau, ʻoi aku hoʻi i nā makahiki i hala iho nei, ʻo Streptococcus pneumoniae ka quinolone-resistant Streptococcus pneumoniae he cross-resistance, ka mea kū i ka penicillin. ʻO nā lāʻau'alopelo macrolide a me nā lāʻau'alopelo quinolone.I ka manawa like, ua ʻike ʻia e hiki i kekahi mau fluoroquinolones ke hoʻolōʻihi i ka manawa QTc o ka electrocardiogram, hepatotoxicity a me phototoxicity, i kaupalena ʻia kā lākou noi.
I mea e lanakila ai i nā hemahema o nā fluoroquinolones i luna, pono e hoʻomohala i nā mea hoʻohui hou me ka hana antibacterial maikaʻi, ākea antibacterial spectrum a me ka liʻiliʻi e like me ka liʻiliʻi o nā hopena ʻino e kūʻē i ka maʻi bacteria kūʻē i nā lāʻau lapaʻau.ʻOkoʻa ka pūʻulu o nā lāʻau lapaʻau fluoroquinolone-free hou (NFQ) i loaʻa i ka 8-methoxyl me nā lāʻau lapaʻau fluoroquinolone no ka mea ʻaʻohe fluorine ma ke kūlana 6 o ka nucleus makua quinolone, akā ikaika mau ka hana antibacterial in vitro.ʻO ka nemonoxacin kahi mea hou NFQ selective bacterial topoisomerase inhibitor.
Hoʻohālikelike ʻia me nā fluoroquinolones i kēia manawa ma ka mākeke, ʻo Nenofloxacin kahi papa hou o nā lāʻau lapaʻau.nemonocacin (TG-873870), he lāʻau quinolone hou i hoʻomohala ʻia e Procter & Gamble (P&G), hōʻike i ka hana antibacterial koʻikoʻi e kūʻē i nā ʻano maʻi pathogens pili pono, me Staphylococcus aureus a me Streptococcus pneumoniae multidrug-resistant.Ua hōʻike ʻia nā hopena o ka hoʻokolohua i nā ʻiole maʻi i ʻoi aku ka ikaika o ka hopena antibacterial o kēia huahana ma mua o ka hapa nui o nā quinolones o kēia manawa.Eia kekahi, loaʻa i ka huahana nā waiwai pharmacokinetic maikaʻi loa a ua ʻae maikaʻi ʻia.