Kina 200124-22-7 Tert-butoxycarbonyl-arginine(Pbf)-OH Mea hana a hale hana |Jiayinglai

200124-22-7 Tert-butoxycarbonyl-arginine(Pbf)-OH

ʻO ka wehewehe pōkole:

Ka nana aku	ʻO ke keʻokeʻo a i ʻole keʻokeʻo keʻokeʻo a i ʻole ka pauka crystalline.
MF	C24H38N4O7S
MW	526.65
Maemae	98+

E hoʻouna i ka leka uila iā mākou

Huahana Huahana

ʻO ke kūlana kaʻaahi a me ke ʻano hoʻouna i ʻōlelo ʻia:
ma ka lewa, ma ke kai a ma ka hoike

Kūlana mālama:
Hoʻopaʻa ʻia i kahi maloʻo, E mālama i loko o ka pahu hau, ma lalo o -20 ° C

Ka helu kauoha liʻiliʻi:
Kūkākūkā

palapala hōʻoia:
COA, HPLC, GC, HNMR, Assay, Water Content(KF), TLC loaʻa

Nā huaʻōlelo like

N5-[[[(2,3-Dihydro-2,2,4,6,7-pentamethylbenzofuran-5-yl)sulfonyl]amino]iminomethyl]-N2-BOC-L-ornithine;
Nα-Boc-Nω-(2,2,4,6,7-pentamethyldihydrobenzofuran-5-sufonyl)-L-arginine;
Nalpha-Boc-Nomega-(2,2,4,6,7-pentamethyl-2,3-dihydrobenzo[b]furan-5-sulfonyl)-L-arginine;
BOC-ARGININE(PBF)-OH;BOC-L-ARG(PBF)-OH;
BOC-N-OMEGA-(2,2,4,6,7-PENTAMETHYLDIHYDROBENZOFURAN-5-SULFONYL)-L-ARGININE

Hoʻopili i loko

Hoʻohana mau ʻia lākou no ka ʻeke pauda.A hiki iā lākou ke pale i ka lā a me ka wai mai ka pōʻino.

kāʻei waho

Hiki i ka pahu paʻakikī ke pale i kāu huahana mai ka hāʻule a pulu.

Nā noi

ʻO Boc-Arg (Pbf) -OH he mea hoʻopuka arginine.
ʻO Bivalirudine, kahi anticoagulant synthetic he 20-peptide cousin o hirudin, ua ʻae ʻia no ke kūʻai ʻana ma ʻAmelika Hui Pū ʻIa i 2000. ʻO ka injection he mea keʻokeʻo, wehe ʻole a i ʻole amorphous solid.Hiki i ka Bivarudine ke hoʻopaʻa pono i ka thrombin catalytic site a me ka anion waho hoʻopaʻa pūnaewele, a keʻakeʻa pololei i ka hana o ka thrombin, no laila ke kāohi nei i ka hopena catalyzed a hoʻoulu ʻia e ka thrombin, a hiki ke hoʻohuli ʻia kona hopena.Hoʻohana nui ʻia ʻo Bivarudine ma ke ʻano he anticoagulant no ka elective percutaneous coronary intervention (PCI) i nā pākeke.
ʻO ka Bivarudine kahi mea paʻa pololei o ka thrombin, kahi e hoʻopaʻa pono ai i nā pūnaewele catalytic a me nā pūnaewele exo-binding anion o ka thrombin free a ma ka thrombus.Hiki ke hoʻohuli ʻia ke kaʻina hana paʻa ma waena o ka bivaludine a me ka thrombin, a hiki i ka thrombin ke hoʻihoʻi i ka hana kūlohelohe mua o ka thrombin ma o ka enzymolysis mālie o ka paʻa peptide ma waena o bivaludine Arg3-Pro4.
Ua hōʻike ʻia nā haʻawina in vitro ʻaʻole hiki i ka bivarudine ke pale wale i ka thrombin lateral free, akā ke kāohi pū hoʻi i ka thrombin i hoʻopaʻa ʻia me nā clots koko me ka ʻole o ka neutralized e nā mea i hoʻokuʻu ʻia e nā platelets.Hiki iā ia ke hoʻolōʻihi i ka manawa prothrombin hapa (APTT), ka manawa thrombin (TT), ka manawa prothrombin (PT) a me ka manawa coagulation ikaika (ACT) i hoʻāla ʻia e ka plasma maʻamau.Aia kahi pilina laina me ka manaʻo o ka bivarudine, akā ʻaʻole maopopo inā loaʻa kēia correlation i ka noi lapaʻau.
Ua hōʻike ʻia i loko o ka puke moʻolelo ʻo ka pharmacokinetics o nā mea maʻi e loaʻa ana i ka percutaneous coronary angioplasty (PTCA) he laina laina ma hope o ka lawelawe intravenous o bivarudine.Hāʻawi ʻia ka mea maʻi i ka 1 mg / kg intravenously e like me ka load dose, a ukali ʻia e kekahi IV infusion o 2.5 mg / kg / hr no nā hola 4, i hoʻopaʻa ʻia ma 12.3 ± 1.7 mg / ml in vivo.Hoʻomaʻemaʻe ʻia ʻo Bivarudine mai ka plasma e ka renal hydrolysis a me ka degradation protease.ʻO ka hapalua o ke ola o ka poʻe maʻi me ka hana renal maʻamau e pili ana i 25min, a ua hoʻonui ʻia ka hapalua o ke ola o nā maʻi me ka haʻahaʻa a me ke koʻikoʻi o ka renal insufficiency.Ma kahi o 25% o ka bivarudine hiki ke wehe ʻia e ka dialysis a hoʻomaʻemaʻe ʻia e ka hemodialysis.Pono e nānā ʻia ʻo ACT i nā mea maʻi me ka hōʻino ʻole o ka renal.I nā limahana olakino, ʻike koke ʻia ka hopena anticoagulant ma hope o ka hoʻokele intravenous o bivarudine, me PT, ACT a me APTT lōʻihi.Hoʻokahi a ʻelua mau hola ma hope o ka haʻalele ʻana, ua hoʻi ʻo ACT i ka pae mua o ka hoʻokele.

huahana pili

Cbz-Phe-Arg-OH	Boc-L-Arg-OH.HCl
Arg-Tyr-Oet	Boc-L-Arg-OH.HCl.H2O
HL-Arg-OH	Boc-D-Arg-OH•HCl•H2O
HD-Arg-OH	Boc-Arg(Cbz)-OH
DL-Arg-OH	Fmoc-L-Arg-OH
L-Arg-Ome.2Hcl	Fmoc-D-Arg-OH
D-Arg-Ome.2HCl	Fmoc-L-Arg(NO2)-OH
L-Arg(Pbf)-OH	Fmoc-L-Arg(Pbf)-OH
D-Arg(NO2)-OH / N-NO2-D-Arg	Fmoc-HoArg(Pbf)-OH
HL-Arg(NO2)-OH	Fmoc-Arg(Tos)-OH
HL-Arg(Tos)-OH	Fmoc-D-Arg(Tos)-OH
L-Arg-NH2	Fmoc-D-Arg(Pbf)-OH
Boc-L-Arg-OH	Cbz-Arg-OH
Boc-D-Arg(Pbf)	Cbz-D-Arg-OH
Boc-Arg-Oet	Cbz-L-Arg(Pbf)-OH
Boc-L-Arg-Ome	Cbz-D-Arg(pbf).CHA
Boc-L-Arg(Tos)-OH	Cbz-D-Arg-Gly-OH
Boc-L-Arg(NO2)-OH	L-Arg(Pbf)-Asp
Fmoc-L-HomoArg-OH	L-Homoarg.hcl

Kiekie

1. Loaʻa ka lawelawe R&D
2. ʻO ka mea hana i hōʻoia ʻia ʻo ISO, hōʻoia maikaʻi
3.A piha piha o ka lawelawe ukali i ka wā hana
4.High kumu kūʻai kūpono
Nā palapala hōʻoia 5.Quality i hāʻawiʻia no ka noi a ka mea kūʻai
6.Great ma hope o ke kūʻai aku, mālama i ka pilina pili me ka mea kūʻai
7.Full punawai e kōkua i ka ho'ēmiʻana i ke kumukūʻai moku
8.Free hāpana hāʻawi ʻia e nānā i ka maikaʻi ma mua o kekahi uku
9.Payment manawa kūkākūkā
10.Assit nā mea kūʻai aku e pili ana i nā hihia ma Kina