13590-42-6 H-Asp(OBzl)-NCA

Ka noiʻi biochemical:
I ka peptide synthesis, lawelawe ʻo H-Asp(OBzl) -NCA ma ke ʻano he hale kūkulu koʻikoʻi no ka synthesis o nā kaulahao peptide i loaʻa nā ʻāpana aspartic acid.
Hana ʻia kāna hui ester benzyl ma ke ʻano he pūʻulu pale, e ʻae ana i ka hoʻokomo ʻana i nā hoʻololi kemika kūikawā i ka wā o ka synthesis chain peptide, a laila hiki ke hoʻoneʻe ʻia ma lalo o nā kūlana kūpono e loaʻa ai ke kaʻina aspartic acid i makemake ʻia.
I loko o nā haʻawina hoʻololi protein a i ʻole peptide, hiki ke hoʻohana ʻia ʻo H-Asp(OBzl) -NCA e hoʻolauna i nā hoʻololi kemika kikoʻī e noiʻi ai i ka hopena o kēia mau hoʻololi i ka hana olaola a i ʻole ka pilina me nā molekala ʻē aʻe o ka protein a i ʻole peptide.
ʻIke lāʻau lapaʻau:
Hiki i ka H-Asp(OBzl)-NCA ke lawelawe ma ke ʻano he synthetic precursor a i ʻole waena no nā molekala lāʻau, e ʻae ana i ka hoʻokomo ʻana i nā hana kemika kūikawā i ka wā o ka hoʻolālā lāʻau e loaʻa ai nā moho lāʻau me nā hana olaola.
Ma o nā hopena me nā ʻāpana lāʻau lapaʻau ʻē aʻe a i ʻole nā ​​molekele hana biologically, hiki iā ia ke hoʻomaʻamaʻa i ka synthesis o nā lāʻau peptide-based a i ʻole heterocyclic pūhui me nā hopena therapeutic kikoʻī.
I nā kaʻina hana ʻike lāʻau, hiki ke hoʻohana ʻia ʻo H-Asp(OBzl) -NCA i ka hoʻāʻo kiʻekiʻe-throughput a me ka hoʻāʻo ʻana i ka hana biological e loiloi i nā hana o nā ʻano peptide like ʻole a i ʻole nā ​​moho lāʻau.
ʻoihana lāʻau lapaʻau:
Ma ka ʻoihana lāʻau lapaʻau, lawelawe ʻo H-Asp(OBzl) -NCA ma ke ʻano he mea maka a i ʻole waena no ka hana ʻana i nā lāʻau peptide therapeutically active.
Ma o nā hopena condensation me nā amino acids a i ʻole nā ​​ʻāpana lāʻau lapaʻau, hiki iā ia ke hoʻomaʻamaʻa i ka synthesis o nā lāʻau peptide me nā hana biological kikoʻī, e like me nā antibiotics, hormones, enzyme inhibitors, a me nā mea hou aku.
ʻO ka pūʻulu benzyl ester i loko o kāna hana e pale i ka waikawa carboxylic o ka waikawa aspartic, e hāʻawi ana i ka paʻa a me ka hana hou o ke kaulahao peptide i ka wā synthesis.