Kina 40216-83-9 H-Hyp-Ome·HCl Mea Hana a hale hana |Jiayinglai

40216-83-9 H-Hyp-Ome·HCl

ʻO ka wehewehe pōkole:

Ka nana aku	Pauda keʻokeʻo
MF	C6H12ClNO3
MW	181.62
Maemae	98+

E hoʻouna i ka leka uila iā mākou

Huahana Huahana

Kūlana halihali
Hiki i ka wela maʻamau

Manaʻo i ke ʻano hoʻouna
Ma ka lewa Ma ka aina Ma ke kai

Kūlana mālama:
E mālama i kahi pōʻeleʻele, Inert ea, lumi wela

Ola ola
Ma kahi o 2 makahiki

Ka nui o ke kauoha liʻiliʻi:
1kg （kūkākūkā）

palapala hōʻoia:COA, wahi hehee, Hoʻololi kikoʻī [α]_D²⁰

E hoʻouna mākou i nā ʻikepili āu e makemake ai.Hiki iā ʻoe ke ʻike i ka ʻikepili ma mua ma ke ʻano he kuhikuhi.

No nā huahana maʻamau, hoʻouna mākou i ka ʻikepili hou ma hope o ka puka ʻana mai.

Nā huaʻōlelo like

H-HYP-OMEHCL;
HL-HYP-OMEHCL;
HYDROXYPROLINE-OMEHCL;
(2S,4R) -trans-4-hydroxy-L-prolinemethylesterhydrochloride;
4-hydroxy-2-pyrrolidinecarboxylicacidmethylesterhydrochloride;
L-4-HYDROXYPROLINEMETHYLESTERHYDROCHLORIDE;
L-4-HYDROXYPROLINEMETHYLESTERHYDROCHLORIDESALT;
L-4-TRANS-HYDROXYPROLINEMETHYLESTERHYDROCHLORIDE

Hoʻopili i loko

Hoʻohana pinepine ʻia lākou no ka hoʻopili ʻana i ka pauka.Pili ia i nā koi o nā mea kūʻai aku.No laila, e haʻi mai iā mākou i kāu koi ma mua o ka hoʻopaʻa ʻana inā loaʻa iā ʻoe nā noi kūikawā.

kāʻei waho

1kg a 25kg He paʻakikī ka paʻi waho.A he mea paʻakikī ke ʻoki a hōʻino.Hiki iā ia ke pale pono i kāu mau huahana.

Nā noi

Hoʻohana: H-Hyp-OMe·HCl lawelawe ma ke ʻano he mea hoʻopili ADC (antibody-drug conjugate) non-cleavable no ka synthesis o nā ADC.ʻO nā ADC, i haku ʻia me kahi antibody a me kahi cytotoxin i hoʻopili ʻia ma o kahi loulou ADC, hiki ke hāʻawi pololei i nā cytotoxins i nā cell target, a laila mālama i nā maʻi kūikawā.Eia hou, ʻo H-Hyp-OMe·HCl kahi mea hoʻopili PROTAC (protein degradation targeting chimera) ma muli o nā kaulahao alkyl, i hoʻohana ʻia i ka synthesis o nā PROTAC.ʻO nā PROTAC, aia nā ligand ʻokoʻa ʻelua i hoʻopili ʻia e kahi mea hoʻopili, hoʻohana i ka ʻōnaehana ubiquitin-proteasome cellular e hoʻohaʻahaʻa i nā protein target.

Pono: H-Hyp-OMe·HCl he pauka amorphous keʻokeʻo a melemele iki paha i hiki ke hoʻoheheʻe ʻia i loko o nā solvents e like me ka wai, methanol, a me ka ethanol.Hōʻike ia i ke kūpaʻa maikaʻi a me ka biocompatibility, mālama i kāna hana a me ke kūpaʻa ma lalo o nā kūlana physiological.

Ma ke ʻano holoʻokoʻa, he kuleana koʻikoʻi ka H-Hyp-OMe·HCl i ka synthesis o ADCs a me PROTAC ma ke ʻano he mea hoʻolaʻa biochemical koʻikoʻi a me nā mea hana hoʻomohala lāʻau.Hāʻawi ia i nā ala a me nā ala hou no ka mālama ʻana i nā maʻi.Ke hoʻomau nei ka noiʻi a me ka ulu ʻana o ka ʻenehana, manaʻo ʻia e hoʻonui ʻia nā manaʻo noiʻi o H-Hyp-OMe·HCl.

huahana pili

L-Hyp-OH	HL-Hyp-Ome·HCl
HL-Hyp-Oet.HCl	L-Hyp-Obzl.Hcl
Boc-L-Hyp-OH	Boc-L-Hyp-Ome
Fmoc-L-Hyp-Ome	Boc-L-Hyp-oet
Fmoc-L-Hyp-OH	Fmoc-L-Hyp(tbu)-OH
Cbz-L-Hyp-OH	Cbz-L-Hyp-OMe

Kiekie

1. Hāʻawi mākou i ka hana maʻamau i nā huahana āu e pono ai.
2. Hiki ke hāʻawi ʻia ke kumukūʻai kiʻekiʻe & hoʻokūkū.
3. Ke hoʻohiki nei mākou i kahi papa hana hahai no ʻoe.
4. Hiki ke hāʻawi ʻia ka nīnau nīnau mea kūʻai aku a me nā palapala ʻenehana inā noi ʻia ma hope o ka hālāwai ʻana i kekahi huina.
5. Nui ma hope o ke kūʻai aku ʻana a i ʻole ka hōʻoia ʻana: E hoʻoponopono koke ʻia kāu nīnau i ka hiki.
6. E hoʻokuʻu aku i nā huahana hoʻokūkū a hoʻokuʻu aku iā lākou i nā ʻāina ʻē i ka nui o kēlā me kēia makahiki.
7. Hāʻawi ʻia ka laʻana manuahi e nānā i ka maikaʻi ma mua o kekahi uku.

Mua: 33208-99-0 L-Ala-NH2.HCl

Aʻe: 7362-93-8 H-Asp-OBzl

E kākau i kāu leka ma aneʻi a hoʻouna mai iā mākou