NUI
No nā nīnau e pili ana i kā mākou huahana a i ʻole ka papa inoa kumukūʻai, e ʻoluʻolu e waiho i kāu leka uila iā mākou a e hoʻopili mākou i loko o 24 mau hola.
NINAU ANOKūlana halihali
Hiki i ka wela maʻamau
Manaʻo i ke ʻano hoʻouna
Ma ka lewa Ma ka aina Ma ke kai
Kūlana mālama:
E mālama i kahi pōʻeleʻele, Inert ea, lumi wela
Ola ola
Ma kahi o 2 makahiki
Ka nui o ke kauoha liʻiliʻi:
1kg (kūkākūkā)
palapala hōʻoia:COA, wahi hehee, Hoʻololi kikoʻī [α]D20
E hoʻouna mākou i nā ʻikepili āu e makemake ai.Hiki iā ʻoe ke ʻike i ka ʻikepili ma mua ma ke ʻano he kuhikuhi.
No nā huahana maʻamau, hoʻouna mākou i ka ʻikepili hou ma hope o ka puka ʻana mai.
BOC-N-METHYL-L-ILE-OH;
BOC-N-METHYL-L-ISOLEUCINE;
BOC-N-ME-ILE-OH;
BOC-N-ME-ISOLEUCINE;
BOC-MEILE-OH;
BOC-MELLE-OH;
BOC-N-ALPHA-METHYL-L-ISOLEUCINE;
BOC-L-MEILE-OH
Hoʻohana pinepine ʻia lākou no ka hoʻopili ʻana i ka pauka.Pili ia i nā koi o nā mea kūʻai aku.No laila, e haʻi mai iā mākou i kāu koi ma mua o ka hoʻopaʻa ʻana inā loaʻa iā ʻoe nā noi kūikawā.
1kg a 25kg He paʻakikī ka paʻi waho.A he mea paʻakikī ke ʻoki a hōʻino.Hiki iā ia ke pale pono i kāu mau huahana.
Peptide Synthesis: ʻO Boc-N-Me-Ile-OH, ma ke ʻano he amino acid i pale ʻia, hoʻohana pinepine ʻia i ka peptide synthesis.Hiki ke hui pū ʻia me nā waikawa amino ʻē aʻe e hana i nā kaulahao peptide me nā kaʻina a me nā hana kikoʻī.
ʻIke ʻana i ka lāʻau lapaʻau: No ka mea he koʻikoʻi nā peptides i nā kaʻina hana olaola, hiki iā lākou ke mālama i nā maʻi like ʻole.Hiki ke lawelawe ʻo Boc-N-Me-Ile-OH ma ke ʻano he ʻāpana i ka synthesis o nā moho lāʻau lapaʻau, e hoʻomaʻamaʻa i ka hoʻomohala ʻana i nā therapeutics-based peptide novel.
Noiʻi Biochemical: Ma nā noiʻi biochemical, hiki ke hoʻohana ʻia ʻo Boc-N-Me-Ile-OH ma ke ʻano he mea paahana a i ʻole ka ʻimi noiʻi e loaʻa ai nā ʻike i nā ʻōnaehana protein, nā hana, a me nā pilina.No ka laʻana, hiki ke hoʻohana ʻia no ka noiʻi ʻana i ka kikoʻī o ka substrate enzyme a i ʻole nā hana paʻa protein-ligand.
Hoʻololi Protein: Hiki ke hoʻohana ʻia ʻo Boc-N-Me-Ile-OH no ka hoʻololi ʻana o nā protein i ka pūnaewele, hoʻokomo i nā hana kikoʻī a hoʻololi paha i kā lākou mau hana olaola.Hiki ke hoʻohana ʻia kēia ʻano hoʻololi i ke aʻo ʻana i ka hana protein a i ʻole e hoʻomohala i nā lāʻau lapaʻau e pili ana i ka protein.
HN-Me-L-Ile-OH | N-Me-L-Ile-Ome.Hcl | Fmoc-N-Me-D-Leu-OH | Cbz-N-Me-L-Ile-OH |
Fmoc-LN-Me-Ile-OH | Boc-N-Me-Ile-OH.DCHA | Cbz-N-Me-D-Leu-OH |
1. No ka MOQ: Hiki iā mākou ke hoʻololi e like me kāu koi.
2. E pili ana i ka hāpana: Pono ka hāpana i ka uku hōʻailona, hiki ke lawe i ka ukana e hōʻiliʻili aiʻole hiki iāʻoe ke uku iā mākou ma mua.
3. Mold workshop, hiki ke hoʻopilikino ʻia e like me ka helu o nā hiʻohiʻona.
4. Hāʻawi mākou i ka lawelawe maikaʻi loa.Ke hana nei kekahi hui kūʻai akamai iā ʻoe.
5. E pili ana i ka hoʻololi: E ʻoluʻolu e leka uila a kamaʻilio mai iaʻu ma kou ʻoluʻolu.