NUI
No nā nīnau e pili ana i kā mākou huahana a i ʻole ka papa inoa kumukūʻai, e ʻoluʻolu e waiho i kāu leka uila iā mākou a e hoʻopili mākou i loko o 24 mau hola.
NINAU ANO,
ʻO ke kūlana kaʻaahi a me ke ʻano hoʻouna i ʻōlelo ʻia:
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Kūlana mālama:
Hoʻopaʻa ʻia i kahi maloʻo, 2-8 ° C
Ka nui o ke kauoha liʻiliʻi:
Kūkākūkā
palapala hōʻoia:
COA, HPLC, GC, HNMR, Assay, Water Content(KF), TLC loaʻa
FMOC-ALA-ALA-OH;
Fmoc-L-Ala-L-Ala-OH;
(S)-2-((S)-2-(((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)propanamido)propanoic acid;
Fmoc-Ala-Ala-OH99%;
FMoc-Ala-Ala;
FMOC-ALA-ALA-OH;
FMOC-L-ALANYL-L-ALANINE;
FMoc-AA-OH;
N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-alanyl-L-alanine
Hoʻohana mau ʻia lākou no ka ʻeke pauda.A hiki iā lākou ke pale i ka lā a me ka wai mai ka pōʻino.
Hiki i ka pahu paʻakikī ke pale i kāu huahana mai ka hāʻule a pulu.
ʻO kēia huahana he polypeptide i haku ʻia me 28 amino acids.No ka N - acetyl - L - siliki ammonia acyl - L - alpha amino ammonia acyl - L - propylene ammonia acyl - L - propylene ammonia acyl - L - valerian ammonia acyl - L - alpha amino ammonia acyl - L - Sue ammonia acyl - L - uea ammonia acyl - L - uea ammonia acyl - L - alpha glutamine - L - ʻokoʻa māmā ammonia acyl - L - Sue ammonia acyl - L - Sue ammonia acyl - L - lai ammonia acyl - L - alpha amino ammonia acyl - L - ʻO ka ammonia acyl kukui - L - lai ammonia acyl - L - alpha - glutamine - L - lai ammonia acyl - L - lai ammonia acyl - L - alpha glutamine - L - valerian ammonia acyl - L - valerian ammonia acyl - L - alpha glutamine - L - alpha - glutamine - L - propylene ammonia waina - L - alpha - glutamine - L - asparagine.E like me ka helu ʻana o ka waiwai anhydrous a me ka acetic acid-free, ʻo ke ʻano o ka thymus (C129 H215 N33O55) he 95.0% ~ 105.0%.
ʻO kēia huahana he pauka keʻokeʻo a keʻokeʻo paha a i ʻole ka nuipaʻa.
Hoʻoheheʻe ʻia kēia huahana i ka waikawa trifluoroacetic, hiki ke hoʻoheheʻe ʻia i ka wai, hiki ʻole ke hoʻoheheʻe ʻia i ka acetonitrile, ether a me trichloromethane.
E lawe i kēia huahana, e kaupaona pololei, e hoʻohui i ka 0.02mol/L phosphate buffer solution (pH 7.0) (e lawe i 2.72g potassium dihydrogen phosphate, e hoʻohui i ka 0.1mol/L sodium hydroxide solution 116.4ml e hoʻoheheʻe, e hoʻoheheʻe me ka wai i 1000ml) a hana i kahi. ʻO ka hopena i loaʻa ma kahi o 5mg i kēlā me kēia 1ml.Hoʻoholo ʻia e like me ke kānāwai (Appendix ⅥE o ka Māhele II o Pharmacopoeia, 2010 edition), pono ka curl kikoʻī -100.0 ° a -110.0 ° ma muli o ka helu ʻana o nā mea anhydrous a me ka acetic acid-free.
ʻAʻole i wehewehe piha ʻia ke ʻano o ka hana o kēia huahana i ka mālama ʻana i ka maʻi hepatitis B a me ka hoʻonui ʻana i ka ʻōnaehana pale.Ua hōʻike ʻia ka nui o nā hoʻokolohua in vitro hiki i kēia huahana ke hoʻoikaika i ka maturation o T lymphocytes ma o ka hoʻoulu ʻana i ka mitogen o nā lymphocytes koko peripheral, hoʻonui i nā pae o interferon α, interferon γ, interleukin 2, interleukin 3 a me nā mea lymphatic ʻē aʻe i huna ʻia e nā cell T. ma hope o ka hoʻoulu ʻana o ka antigen a i ʻole mitogen, a i ka manawa like e hoʻonui ai i ke kiʻekiʻe o nā mea hoʻokipa lymphofactor ma ka ʻili o nā cell T.Hiki iā ia ke hoʻonui i ka pane o allogeneic a me autologous kanaka i hui pū ʻia nā lymphocytes ma o ka hoʻāla ʻana o nā cell CD4.Hiki i kēia huahana ke hoʻonui i ka hōʻuluʻulu o nā cell pre-NK, a hiki i ka interferon ke hoʻonui i ko lākou cytotoxicity.Ua hōʻike ʻia nā hoʻokolohua in vivo hiki i kēia huahana ke hoʻonui i ka pae hōʻike o ka interleukin-2 receptor a me ka pae huna o interleukin-2 i loko o nā lymphocytes ʻiole ma hope o ka hoʻoulu ʻana o cancanadin A.
Gly-Ala-Ome.hcl | Fmoc-L-Ala-OH | β-Ala-Ome.HCl | L-Ala-Phe-OH |
Gly-Gly-Ala-Ome.hcl | Fmoc-DL-Ala | HL-Ala-Ome.Hcl | L-Ala-Leu-OH |
L-ALa | Fmoc-D-Ala-OH | β-Ala-Otbu.HCl | L-Ala-Pro-OH |
DL-ALA | Fmoc-β-Ala-OH | DL-Ala-Otbu.Hcl | DL-Ala-DL-Val |
H-Ala-ol | Fmoc-LN-Me-Ala-OH | L-Ala-NH2.HCl | Ala-Gly-Ome.hcl |
β-Ala-ol | Fmoc-N-Me-D-Ala-OH | HD-Ala-NH2·HCl | L-Ala-Ala-Obzl.HCl |
D-ALa | Fmoc-Ala-Cl | HD-Ala-NH2 | D-Ala-D-Ala-Ome.Hcl |
H-β-Ala-OH | Fmoc-L-Ala-Ol | Ac-L-Ala-NH2 | H-Ala-Ala-Otbu.HCL |
HN-Me-L-Ala-OH | fmoc-β-Ala-NH2 | Ac-D-Ala-NH2 | Boc-Ala-Phe-OH |
HN-Me-D-Ala-OH | Fmoc-Ala-Ome | AC-D,L-Ala-OH | Boc-L-Ala-Leu |
L-Ala-NCA | Fmoc-Ala-Osu | Ac-D-Ala-OH | Boc-ALa-Val-OH |
D-Ala-NCA | fmoc-β-Ala-osu | AC-L-Ala-OH | Boc-Ala-Pro |
L-Ala-nbu.hcl | Cbz-L-Ala-OH | AC-L-Ala-OME | Boc-Ala-Gly-OH |
L-Ala-Otbu | Cbz-D-Ala-OH | Pht-D-Ala | Boc-Ala-Ala-OH |
D-ALa-Oipr.HCL | Cbz-N-Me-L-Ala-OH | Pht-L-Ala | Boc-Ala-Ala-Ome |
D-Ala-Otbu.Hcl | Cbz-N-Me-D-Ala-OH | Boc-L-Ala-OH | Boc-Ala-Ala-Obzl |
N-Me-L-Ala-OMe | Cbz-DL-Ala-OH | Boc-D-Ala-OH | Fmoc-Ala-pro |
HD-Ala-OBzl·HCl | Z-β-L-Ala-OH | Boc-DL-Ala-OH | Fmoc-Ala-gly-OH |
β-Ala-Obzl.Tos | Cbz-L-Ala-OL | Boc-β-Ala-OH | Fmoc-L-Ala-Ala-OH |
H-Ala-OBzl·HCl | Cbz-L-Ala-NH2 | Boc-N-Me-Ala-OH | Fmoc-β-Ala-D-phe |
HL-Ala-OBzl.Tos-OH | Cbz-L-Ala-Ome | Boc-N-Me-DL-Ala-OH | Fmoc-β-Ala-D-Tyr(Et) |
HD-Ala-Oet.HCl | Cbz-D-Ala-OMe | Boc-N-Me-D-Ala-OH | Cbz-Ala-Val-OH |
HL-ALa-Oipr.HCL | Cbz-Beta-Ala-Ome | Boc-L-Ala-Ol | Cbz-L-Ala-Ala-OH |
N-Me-Ala-Otbu.Hcl | Cbz-β-Ala-Otbu | Boc-D-Ala-Ol | Cbz-Ala-Pro-OH |
HL-Ala-OtBu·HCl | Cbz-L-Ala-Osu | Boc-DL-Ala-Ol | Cbz-L-Ala-Leu-OH |
H-DL-Ala-OMe.HCl | Cbz-Beta-Ala-OSU | Boc-Ala-NH2 | Cbz-L-Ala-Ala-Ome |
β-Ala-Oet.HCl | Ala-Ala-OH | Boc-D-Ala-NH2 | Ala-Ala-Ome.HCL |
N-Me-L-Ala-Ome.hcl | Ala-gly | Boc-β-Ala-NH2 | Val-Ala |
HD-Ala-Ome.Hcl | L-ALa-Val-OH | Boc-D-4-Chloropheny(alanine) | Boc-Ala-Pro |
Boc-L-ALA-OBZL | Boc-Leu-Ala | Boc-D-3(1-Naphthgl)-alanine | Boc-Val-Ala |
Boc-L-Ala-OSu | Fmoc-leu-ala | Boc-L-Ala-Ome | Cbz-Val-Ala-OH |
Boc-L-Beta-Ala-Osu | Cbz-Leu-Ala-OH | Boc-D-Ala-OMe | Cbz-Val-Ala-Ome |
Boc-D-Ala-OSu | Phe-Ala | Boc-L-Ala-Otbu | Leu-Ala-OH |
Fmoc-L-Ala-OH.H2O | Boc-Phe-Ala-OH | Z-Lys(boc)-Ala-Ala-OBzl | HL-Thr-OBzl·oxalate |
HL-Thr(Bzl)-OBzl.oxalate | Cbz-Phe-Ala-OH |
1. Loaʻa ka lawelawe R&D
2. ʻO ka mea hana i hōʻoia ʻia ʻo ISO, hōʻoia maikaʻi
3.A piha piha o ka lawelawe ukali i ka wā hana
4.High kumu kūʻai pono
Nā palapala hōʻoia 5.Quality i hāʻawiʻia no ka noi a ka mea kūʻai
6.Great ma hope o ke kūʻai aku, mālama i ka pilina pili me ka mea kūʻai
7.Full punawai e kōkua i ka ho'ēmiʻana i ke kumukūʻai moku
8.Free hāpana hāʻawi ʻia e nānā i ka maikaʻi ma mua o kekahi uku
9.Payment manawa kūkākūkā
10.Assit nā mea kūʻai aku e pili ana i nā hihia ma Kina